UKHC Cardiologist Named President of the KYACC

Posted: 3/1/2021
Dr. Gretchen Wells, director of UK HealthCare Women’s Heart Program at the Gill Heart & Vascular Institute, will assume office as president of the Kentucky Chapter of the American College of Cardiology (KYACC), and will serve on the Board of Governors for ACC.In this role, Wells will lead KYACC initiatives to improve access to cardiovascular care across the Commonwealth.“Dr. Wells is uniquely well-suited to lead KYACC during this unprecedented time,” said Stephanie Czuhajewski, who serves as the KYACC executive director. “Her clinical and leadership experience will be invaluable to KYACC efforts to optimize interdisciplinary care along the... FULL STORY
Tags: Surgery, Research

UK Study Shows FDA-approved Leukemia Drug May Help Treat Metastatic

Posted: 11/3/2020
A new study led by researchers at the University of Kentucky Markey Cancer Center and UK Department of Pharmacology and Nutritional Sciences demonstrates the potential benefit of using an anti-leukemic drug nilotinib – most commonly used to treat chronic myelogenous leukemia – to overcome therapy resistance in metastatic melanoma.In the study, published in Nature Communications, the researchers used cell culture and animal models to demonstrate that nilotinib, an ABL kinase inhibitor, may provide benefit for patients with metastatic melanoma who have developed resistance to the current standard-of-care drug regimens.Melanoma is an... FULL STORY
Tags: Pharmacology and Nutritional Sciences, Research

UK College of Medicine Honors Henrietta Lacks’s Legacy

Posted: 10/5/2020
Henrietta Lacks’s “HeLa” cells continue to influence scientific discovery even after her death from cancer in 1951. These cells have been used to study cancer growth, learn more about viruses, and study drug effects on the body. They even helped develop the polio vaccine.While her impact in medicine is widespread, Lacks’s story also has sparked important ethics discussions because her cells were used for research without her permission. On Thursday, Oct. 1, the UK College of Medicine’s Students Embracing Equity in Medical Sciences (SEEMS) hosted “Black Lives Matter Immortalized: CELLebrating the Legacy of Henrietta Lacks.” The virtual event provided a forum for... FULL STORY
Tags: ODEI, henrietta lacks, research

UK Research Could Pave Way for Noonan-like Syndrome Treatment

Posted: 7/1/2020
A University of Kentucky College of Medicine researcher has been awarded $1.9 million to continue research examining molecular pathogenesis of Noonan-like syndrome. Emilia Galperin, Ph.D., professor in the Department of Molecular... FULL STORY
Tags: Research

It’s Not Just Alzheimer’s Disease: Sanders-Brown Research Highlights Form

Posted: 6/29/2020
The long-running study on aging and brain health at the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) Alzheimer’s Disease Center has once again resulted in important new findings – highlighting a complex and under-recognized form of dementia. The work was recently published in The Journal of the American Medical Association (JAMA): Neurology. “One of the things that we’ve learned in the last decade or so is that a lot of people that we think have dementia from Alzheimer’s disease, actually don’t. There are other brain diseases that cause the same kind of symptoms as Alzheimer’s, including some that we only recently figured out existed,” said Erin... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Research

UK Ophthalmologist Writes Article Highlighting Limited and Inconsistent

Posted: 6/25/2020
Dr. Daniel Moore, from the University of Kentucky College of Medicine’s Department of Ophthalmology and Visual Sciences, recently conducted a study looking at the frequency and use of racial and ethnic data in ophthalmology literature published throughout 2019. He wrote an article outlining his findings which was published in The Journal of the American Medical Association: Ophthalmology. Moore says the description of racial and ethnic data in human trials is relatively unregulated which can lead to confusion and inconsistent reporting. In the article, he writes, “The use of race and ethnicity in the medical literature is historically and currently controversial, with... FULL STORY
Tags: Research

Artemisia Annua Could Be Promising Treatment for COVID-19

Posted: 6/25/2020
Recent lab studies by chemists at the Max Planck Institute of Colloids and Interfaces (Potsdam, Germany) in close collaboration with virologists at Freie Universität Berlin have shown that extract from the medicinal plant Artemisia annua, also known as Sweet Wormwood, is active against SARS-CoV-2, the virus that has caused the COVID-19 pandemic. The new potential treatment has been added to the University of Kentucky’s innovative clinical trial for experimental COVID-19 therapies, which was launched by leaders from UK’s Markey Cancer Center, College of Medicine and College of Pharmacy in May. The new arms of the clinical trial will test the effectiveness of... FULL STORY
Tags: Research

Alpacas Could be the Secret Weapon Against COVID-19

 Antibodies from Big Boy, Emperor and Blue Eyes are helping UK researchers understand COVID-19 and potentially develop a treatment that could protect people from being infected. Photo by Ben Corwin, Research Communications. Posted: 6/19/2020
LEXINGTON, Ky. (June 18, 2020) — Alpacas Big Boy, Blue Eyes and Emperor may hold the key to combating COVID-19. Their antibodies could offer a defense against SARS-CoV-2, the virus that causes the disease.University of Kentucky College of Medicine researchers are using the special antibodies made by alpacas, called nanobodies, to help understand the novel coronavirus and potentially develop a treatment that could protect people from being infected. Nanobodies are smaller and more stable types of antibodies taken from the immune systems of camelids – which include camels, llamas and alpacas. Nanobodies could be more effective at fighting the disease... FULL STORY
Tags: Research, Research

UK College of Medicine, UK HealthCare Launch New START Trial to Assess

Posted: 6/17/2020
The University of Kentucky College of Medicine and UK HealthCare have launched a new clinical trial designed to assess the prevalence of COVID-19 in central and eastern Kentucky. Known as Serologic Testing to Accelerate Recovery and Transition (START), the study focuses on antibody testing to begin understanding how many people in the region may have already contracted and recovered from COVID-19. The trial is a partnership between the UK College of Medicine, UK HealthCare Infection Prevention and Control (IPAC), the UK Markey Cancer Center, and University Health Service, and is co-led by IPAC Medical Director Dr. Derek Forster and Precision Medicine Clinic Director... FULL STORY
Tags: Covid-19, Research

PILOT PROJECT FUNDING OPPORTUNITY

Posted: 6/2/2020
The NIH Center of Biomedical Research Excellence (COBRE) on Obesity and Cardiovascular Diseases, in collaboration with the Center for Clinical and Translational Sciences (CCTS) announce the availability of limited funds to support pilot projects focused on research examining obesity-associated diseases. Emphasis for support will be placed on pilot projects that examine the relationship between obesity and cardiovascular diseases, type 2 diabetes, COVID-19, cancer, or neurodegenerative diseases.  These pilot grants are intended to assist investigators new to this area of research to generate sufficient data to be competitive for extramural funding. ... FULL STORY
Tags: Research

Neuroscience Researchers Keep Momentum Going with Online Seminar Series

Posted: 5/18/2020
Mere days after the COVID-19 pandemic forced limitations on research in laboratories, a team of neuroscience-related researchers from the UK College of Medicine figured out a way to keep the important discussions going, virtually.The team’s solution: developing an online seminar series discussing a wide variety of topics in neuroscience, which is one of the six research priority areas in the UK Vice President for Research’s Research Priorities Initiative.Lance Johnson, PhD, assistant professor in the department of physiology and researcher with the UK Sanders-Brown Center on Aging, said the idea derived from an interaction with a colleague from Europe, Dr. Rik van der... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Neuroscience, Research

UK Launches Clinical Trial to Evaluate Novel Treatments for COVID-19

Posted: 5/8/2020
Clinical leaders from the University of Kentucky’s Markey Cancer Center, College of Medicine and College of Pharmacy have launched a clinical trial for experimental therapies to treat patients infected with COVID-19. The trial will investigate the effectiveness of azithromycin, ivermectin and camostat mesylate—drugs that could inhibit replication of SARS-CoV-2, the virus that causes the disease. The three will be tested either as stand-alone therapies or in combination with the antimalarial drug hydroxychloroquine. The trial has a “pick-the-winner” design, which will allow UK researchers to rapidly understand what potential therapies appear to be effective, guiding... FULL STORY
Tags: Research