UK, Kentucky Awarded $87 Million to Lead Effort in Combating Nation's

Posted: 4/18/2019
In the largest grant ever awarded to the University of Kentucky, researchers from UK's Center on Drug and Alcohol Research (CDAR) and across campus — in partnership with the Kentucky Cabinet for Health and Family Services and the Justice and Public Safety Cabinet (JPSC) — will lead a project as part of the HEALing Communities study.The four-year, more than $87 million study has an ambitious but profoundly important goal: reducing opioid overdose deaths by 40 percent in 16 counties that represent more than a third of Kentucky’s population.The university’s largest previous grant was a $25 million award for math and science education in Appalachia.More... FULL STORY
Tags: Opioid Treatment, Research, Grants and Funding

Mark Williams, MD and Jing Li, MD, MS Share Findings at CMS National Care

Posted: 4/17/2019
Mark Williams, MD, Chief Quality and Transformation Officer at UK HealthCare and Director of the University of Kentucky Center for Health Services Research, and Jing Li, MD, MS, Associate Director of the UK Center for Health Services Research, presented the findings from Project ACHIEVE at the National Care Transitions Awareness (NCTA) Day Summit, which was held on NCTA Day, April 16. National Care Transitions Awareness Day aims to increase awareness of the critical transition that patients and their caregivers experience when they transition from the hospital to home or other site of care.In honor of the awareness day, the Centers for Medicare and Medicaid Services (CMS... FULL STORY
Tags: Center for Health Services Research, Research

A "Low Dose Aspirin" for Dementia? Drug Ready for Human Testing

Posted: 4/3/2019
Alzheimer's disease wreaks emotional havoc on patients, who are robbed of their memories, their dignity, and their lives.  It’s financially devastating as well: care for Alzheimer's patients is predicted to top $1 trillion by about the time children born today are having children of their own.To date, there have been very few successes in the pursuit of a treatment. But one drug that looks at Alzheimer's Disease (AD) from a different angle is now ready for its first round of testing in humans.The vast majority of Alzheimer's treatments currently FDA-approved or in the pipeline target amyloid, which is responsible for the hallmark plaques that interfere... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Dementia, Research

Does Smoking Cause Dementia? Maybe Not, Study Says

Posted: 3/26/2019
It's an irrefutable fact that smoking is bad for you. Study after study has proven that smoking increases your risk for cancer, heart disease, diabetes – even blindness.But dementia? Not so fast. A recent study has demonstrated that smoking is not associated with a higher risk of dementia. Many previous studies have found a correlation between smoking and dementia. However, Erin Abner of the University of Kentucky's Sanders-Brown Center on Aging(SBCoA) and colleagues wanted to explore outcomes using a different method of data analysis."The underlying data [in those studies] was solid, but the analysis didn't take into account the idea of competing... FULL STORY
Tags: Alzheimer's disease and related dementias, Research

$2.3 million NIH Grant Aims to Help Improve Diversity in Science and

Posted: 2/19/2019
Through a recent five-year, $2.3 million grant from the National Institutes of Health (NIH), University of Kentucky faculty Don Frazier and Brett Spear will partner with faculty from qualified minority-serving institutions across the U.S. and Puerto Rico to help improve diversity in science and health care. The money will enable the creation of Innovative Programs for Enhancing Research Training (IPERT), focused on mentoring these faculty in grant-writing and teaching skills. In addition to Frazier and Spear, the project is led by campus-wide team of grant specialists and research faculty.Frazier, whose name now adorns the UK Outreach Center for... FULL STORY
Tags: Research, Faculty

Clinical Trial Gives UK Pathologist New Hope

Posted: 2/5/2019
As a longtime pathologist at the University of Kentucky, Dr. Charles Lutz is no stranger to cancer.Lutz has spent much of his career in the lab, helping patients behind the scenes. At the UK Markey Cancer Center, he works in molecular diagnosis and HLA tissue typing in bone marrow transplantation for leukemia and other cancers. He also helps match patients in end-stage organ failure with an appropriate solid organ transplant for the UK Transplant Center.But when he was diagnosed with an aggressive form of prostate cancer in 2011, the doctor became the patient. Over the next few years, he would undergo extensive surgery and radiation treatments to... FULL STORY
Tags: Clinical Trials, Faculty, Research

Research Identifies Pathway Connecting Some HIV Drugs With Liver Disease

Posted: 2/1/2019
As a raft of new treatments for HIV infection have come on the market in the past 20 years, AIDS patients have gotten access to drugs that allow them to live longer."These drugs are miracles," said Dr. Richard N. Greenberg, an infectious disease specialist at the University of Kentucky. "Before the advent of anti-retroviral drugs, HIV infection was a death sentence. Now, taken properly, the life span of a person with an HIV infection is practically normal."However, many of these anti-retroviral (ARV) drugs — most notably a class of drugs called Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) — have been associated with liver disease. In fact, liver disease... FULL STORY
Tags: Pharmacology and Nutritional Sciences, Research

Sci-Fi to Reality: Superpowered Salamander May Hold Key to Human

Posted: 1/24/2019
Regeneration is one of the most enticing areas of biological research. How are some animals able to regrow body parts? Is it possible that humans could do the same? If scientists could unlock the secrets that confer those animals with this remarkable ability, the knowledge could have profound significance in clinical practice down the road.  Scientists at the University of Kentucky have taken this concept one step closer to reality, announcing today that they have assembled the genome of the axolotl, a salamander whose only native habitat is a lake near Mexico City.Axolotls have long been prized as models for... FULL STORY
Tags: scobirc, Research

Study Links Smoking During Pregnancy With Increase in Obesity Later in

Posted: 1/16/2019
University of Kentucky researchers have identified a potential cellular mechanism that connects a mother's smoking while pregnant with an increased risk in the offspring's obesity later in life. Obesity is considered an epidemic in the U.S., with nearly 35 percent of adults and 20 percent of children six to 19 years old deemed obese. Obesity is a serious economic burden as well: more than $150 billion is spent annually on obesity-related healthcare costs in the U.S. alone."It has been consistently shown that mothers who smoke during pregnancy confer increased risk of obesity to their baby, but the mechanisms responsible for this increased risk are not... FULL STORY
Tags: OB, Research

Daret St. Clair Receives Lifetime Achievement Award from International

Posted: 11/27/2018
University of Kentucky Markey Cancer Center researcher Daret St. Clair, Ph.D., has been named the 2018 Lifetime Achievement Award Recipient from the Society for Redox Biology and Medicine (SfRBM). St. Clair received the award and gave a feature lecture at the SfRBM’s 25th Annual Conference in Chicago earlier this month.St. Clair's career is marked by her seminal work on the role of manganese superoxide dismutase (MnSOD) in cancer development and therapy. Her research has resolved long-debated questions about MnSOD expression in cancer and has demonstrated that the presence of MnSOD inversely regulates the induction and progression of cancer.Her... FULL STORY
Tags: Faculty, Research

UK Biochemist Recognized for Work in FUS-ALS

Posted: 11/21/2018
Researchers at the University of Kentucky have discovered new biological processes by which mutations in the FUS gene cause neurodegeneration in amyotrophic lateral sclerosis (ALS).FUS is a DNA and RNA binding protein that resides predominantly in the nucleus and appears to play a role in DNA repair and RNA metabolism. In contrast, ALS-related mutations cause the protein to accumulate in the cytoplasm, which can contribute to inclusion bodies – the pathological hallmarks of disease – and neurotoxicity.A group led by Haining Zhu, a professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky, discovered that ALS-causing... FULL STORY
Tags: Biochemistry, Research

Research Identifies Potential Predictors of Vascular Cognitive Impairment

Posted: 11/7/2018
Research at the University of Kentucky Sanders-Brown Center on Aging has identified two potential ways to predict vascular cognitive impairment and dementia (VCID) – the second leading cause of dementia behind Alzheimer's disease.VCID results from injuries to the vessels that supply blood to the brain, including mini-strokes, and/or by risk factors that are also known to cause heart disease or stroke:  high cholesterol, smoking, high blood pressure and/or diabetes. About 10 percent of all dementia cases are caused by VCID, while Alzheimer's accounts for between 60 and 80 percent. Sometimes Alzheimer's and VCID can occur simultaneously, which is... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Research