New Study Discovers "Killer Peptide" That Helps Eliminate

Posted: 8/4/2017
A new study by University of Kentucky Markey Cancer Center researchers shows that when therapy-sensitive cancer cells die, they release a "killer peptide" that can eliminate therapy-resistant cells.Tumor relapse is a common problem following cancer treatment, because primary tumor cells often contain therapy-resistance cancer cells that continue to proliferate after the therapy-sensitive cells have been eliminated.In the new study, published in Cancer Research, Markey scientists identified a Par-4 amino-terminal fragment (PAF) that is released by diverse therapy-sensitive cancer cells following therapy-induced cleavage of the tumor suppressor Par-4... FULL STORY
Tags: Research, Cancer

Matthew Gentry: Biofuels, Epilepsy and Science Advocacy

Posted: 7/26/2017
By Vice President for Research Lisa Cassis ThursdayIn May, it was my distinct pleasure to present Matthew Gentry with a University Research Professorship award. He was one of 16 faculty, selected by their own colleges, who have demonstrated excellence in scholarship and creative work that addresses scientific, social, cultural and economic challenges in our region and around the world.Gentry, a professor of molecular and cellular biochemistry in the College of Medicine, has received an NSF Faculty Career Development Award, NIH Pathway to Independence Award, three U.S. patents, and a five-year, $8.5 million NIH grant to pursue a cure for Lafora disease, a deadly... FULL STORY
Tags: Research

Physician-Pharmacist Teams Benefit Brain Health in Older Patients

Posted: 7/19/2017
New findings from University of Kentucky faculty published in Alzheimer’s Research and Therapy demonstrate the value of physician-pharmacist teams in providing elderly care.As people age, the number of prescribed medications tends to increase, raising the level of complexity for both patient care and medication therapy. In the United States, patients over 60 take an average of five different medications, many of which are prescribed by different physicians. This complexity often results in a higher probability of inappropriate drug prescriptions and side effects, including cognitive impairment.This is especially relevant for patients living with Alzheimer’s... FULL STORY
Tags: Research

The People Behind Our Research: "You Have to Follow the Science Where

Posted: 7/17/2017
A peek at Matthew Gentry's professional profile reveals a long list of honors and awards.A National Science Foundation Faculty Career Development Award.A National Institutes of Health Pathway to Independence Award.A University of Kentucky Research Professorship Award.Three U.S. Patents.A five-year, $8.5 million National Institutes of Health grant to pursue a cure for Lafora disease.Wait. Lafora disease? From a lab that also studies biofuels?"I began my career studying plant proteins and am now working on human diseases," Gentry says. "You have to be willing to go where the science takes you."In Gentry's case, the journey began when he found that a certain plant protein... FULL STORY
Tags: Research

UK Center for Health Services Research Awarded $4.5 Million from CMS for

Posted: 7/10/2017
With a $4.5 million award from the Centers for Medicare and Medicaid Services, researchers in the University of Kentucky Center for Health Services Research (CHSR)  have established the Kentucky Consortium for Accountable Health Communities (KC-AHC) to address the health-related social needs of vulnerable patients across the Commonwealth.Over the next five years, principal investigator and director of the CHSR, Dr. Mark V. Williams, along with co-principal investigator Dr. Jing Li, are partnering with the Kentucky Primary Care Association (KPCA), Appalachian Regional Health, Norton Health Care and Kentucky HomePlace... FULL STORY
Tags: Center for Health Services Research, Research

New Book by UK Faculty Member Guides STEM Students in Career Planning

Posted: 6/2/2017
A new book co-written by Nathan Vanderford, University of Kentucky assistant professor in the Department of Toxicology and Cancer Biology, guides STEM graduate and postdoctoral students in their career planning by evaluating goals and finding the steps to be taken to achieve them.In ReSearch: A Career Guide for Scientists, authors Nathan L. Vanderford, Teresa M. Evans and Natalie Lundsteen help students with their career planning practices, particularly in the sciences. This step-by-step guide provides global perspectives and strategies on seeking career opportunities.“The overall goal of the book is to provide graduate trainees with the knowledge they... FULL STORY
Tags: Research

Third Annual Appalachian Research Day Shares Results of Health Studies

Posted: 6/1/2017
The Third Annual Appalachian Research Day was held May 24 in Hazard, Ky., hosted by the University of Kentucky Center of Excellence in Rural Health (CERH). The event invites researchers and community members to “come sit on the porch” and share research findings with the local communities involved in the studies.  Rural Appalachian communities experience some of the most severe health disparities in the nation, and community-based research is an effective method to identify problems and develop collaborative, effective solutions.This type of engaged research begins at the local level, built upon the foundation of relationships with individuals, neighborhoods, and... FULL STORY
Tags: Center of Excellence in Rural Health, Research

Basic Research Vital to Health, Well-being of State, Country

Posted: 5/15/2017
 Colorectal cancer incidence rates have declined by 25 percent in Kentucky in less than 10 years. Death rates have dropped by 30 percent.Why?Among other reasons, screenings have increased significantly, led by University of Kentucky researchers along with changes in state policy.It’s one example of the impact of basic scientific research combined with outreach into communities across Kentucky. Basic scientific research is at the cornerstone of each innovative step and – led by UK – it is leaving an impact across Kentucky.“Everything that we do came from a research question that was originally asked by someone either in the U.S. or... FULL STORY
Tags: Research

Research-Based Training to Identify Substance Misuse

Posted: 5/10/2017
Even when it’s your job, it’s not easy to ask people about substance use. Kalea Benner’s current research is based on this fact.“I knew from my own experiences as a social work practitioner, even with a decade of experience under my belt, it was still hard for me to ask about substance use. And, in today's world, when it's prescription drugs, when a doctor has given you permission to use that medication, it's even harder,” says Benner, director of undergraduate studies at the UK College of Social Work. “That was one thing I wanted to help my students do: gain confidence in asking those tough questions, know that they weren't being intrusive, and be able to... FULL STORY
Tags: Research

Markey and LLS Host Sixth Annual ‘Meet the Researcher Day’

Posted: 5/3/2017
The University of Kentucky Markey Cancer Center and the Leukemia and Lymphoma Society (LLS) recently hosted their sixth annual "Meet the Researcher Day" on April 27- 28. Meet the Researchers Day is a field trip given as a prize to schools in the region who successfully raise more than $1,000 for the LLS's Pennies for Patients campaign.This year, Shelby County West Middle School, Mercer County Senior High School, New Albany High School and Henry County Middle School won the opportunity to visit the Biomedical/Biological Sciences Research Building (BBSRB) on UK's campus and learned more about how the money they raised for Pennies for Patients will help... FULL STORY
Tags: Research, Markey Cancer Center

The NIH Institutional Development Award (IDeA): A Program of Impact

Posted: 4/26/2017
By Vice President for Research Lisa Cassis Recently, we celebrated a new grant from the National Institutes of Health (NIH), within a program called the Institutional Development Award (IDeA), for a Center for Cancer and Metabolism. This Center of Biomedical Research Excellence (COBRE), which is headed by Daret St. Clair in collaboration with Peter Zhou, is anticipated to have an amazing impact on our ability to fight the cancer scourge that plagues Kentucky.So what exactly is the NIH IDeA program, what is a COBRE (no, it’s not a snake), and why would these programs have such an impact on cancer research at UK? Let’s start with the NIH IDeA program. This... FULL STORY
Tags: Research

"Our Story" Featured at Sanders-Brown Annual Dinner

Posted: 4/24/2017
They've hosted astronauts, entrepreneurs, national champions, politicians and world leaders.  But this year, the University of Kentucky Sanders-Brown Center on Aging opted to tell "Our Story" at its annual dinner.Instead of a keynote speaker from outside the organization, Sanders-Brown featured the stories of six families whose lives have been ravaged by Alzheimer's disease.Called "Our Story," this emotional journey of wives, sons, husbands and daughters tells how Sanders-Brown helped them cope with the financial, psychological and emotional impacts of their loved ones' diagnosis – and how many of them are giving back by participating in research at... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Research