UK to Announce Major Multi-million NIH Grant to Launch New Center to Fight

Posted: 4/17/2017
The University of Kentucky was recently awarded a prestigious Centers of Biomedical Research Excellence (COBRE) grant to study the metabolism of cancer from the National Institutes of General Medical Sciences, part of the National Institutes of Health. The $11.2 million grant will fund UK's Center for Cancer and Metabolism over the next five years.Kentucky has disproportionately high incidences of both cancer and metabolic disorders and leads the nation in cancer deaths and is in the top 10 for highest obesity rates in the country. While scientists have long known of a direct link between obesity and cancer, the need for further research into this field is a necessity... FULL STORY
Tags: Research, Markey Cancer Center

Proposed Cuts to Federal Research Funding Threaten UK’s Health and High-

Posted: 4/13/2017
In December, with bipartisan support, Congress passed the 21st Century Cures Act, a major piece of legislation designed to re-energize medical research within the National Institutes of Health (NIH) – the world’s premier biomedical research government agency. But the recently released so called “skinny” budget within the America First budget blueprint, which includes a roughly $6 billion cut to the NIH, would profoundly curtail discovery and innovation across the U.S.Members of the House and Senate from both parties have voiced their doubts about such cuts in federal funding for research and discovery, and the budget in its current form is by no means what will... FULL STORY
Tags: Research

VPR Workshop: Core Facilities Supported by Research

Posted: 4/6/2017
By Vice President for Research Lisa Cassis Thursday The Office of the Vice President for Research is hosting a series of workshops designed to help faculty accelerate their research activities and utilize the capabilities of core facilities. For more workshops, see the Research Support Guide. CORE FACILITIES SUPPORTED BY UK RESEARCH: April 13, 202A BBSRB, 1:30 p.m. – 3:15 p.m. Who should attend: All researchers who require the advanced capabilities of Research-supported core facilities. Directors and staff from the facilities (listed below) will provide an overview of equipment and services available to UK investigators. 1:30 p.m. Introduction to Research-... FULL STORY
Tags: Research

Neurology Resident's Study, Published in Stroke, Proposes Change to

Posted: 2/22/2017
Organizations like the American Heart Association have promoted the FAST concept to help people recognize the symptoms of stroke.FAST stands for Face, Arm, Speech and Time – the last letter a reminder to seek treatment immediately because strokes can be debilitating or even deadly.However, a study published in a recent issue of Stroke and authored by a resident physician at the University of Kentucky might signal a sea change in how we educate lay people and first responders to look for stroke.Dr. Susanth Aroor, a fourth year neurology resident at the University of Kentucky, was inspired by a conversation with Dr. Larry B. Goldstein, chairman of the University... FULL STORY
Tags: Research, Neurology

Parkinson's disease research and treatment with Dr. Craig van Horne

Posted: 2/20/2017
Parkinson’s disease is a long-term, progressive disorder of the nervous system that affects movement. An estimated seven to 10 million people worldwide are living with Parkinson’s. The symptoms for the disease usually develop slowly over time, and among the obvious are shaking, rigidity, slowness of movement, and difficulty in walking. Currently, there is no cure for Parkinson’s, though there are medications that can slow the progression of symptoms.Dr. Craig van Horne is an associate professor of neurosurgery with UK HealthCare. He focuses his research on cellular and surgical therapies for Parkinson’s disease.Deep Brain Stimulation, or DBS, is a surgical procedure... FULL STORY
Tags: Parkinson's disease, Research

Behind the Blue Examines Women's Heart Health With Dr. Gretchen Wells

Posted: 2/10/2017
February is American Heart Health Month, and this past Feb. 3 marked the 14th annual National Wear Red Day for Women. It’s a day designed to call our attention to recognizing heart disease as the No. 1 killer of women in this country, and to raise awareness of women’s overall heart health.According to the Centers for Disease Control, heart disease is the leading cause of death for women in the United States, and in 2013 was responsible for about one in four female deaths. It’s generally thought of as a “man’s disease,” but heart disease affects genders equally in the U.S., and only 54 percent of women recognize that it is their No. 1... FULL STORY
Tags: Research, Gill Heart Institute

Norton, UK Partner on Clinical Trial for First-Ever Treatment of Radiation

Posted: 1/23/2017
Radiation therapy saves countless lives, but in rare cases, it can cause a debilitating, long-term complication when used on the brain. Around three to five percent of patients who receive radiation for brain tumors, or arteriovenous malformations (AVM), develop radiation necrosis, where the brain tissue around the targeted lesion becomes injured and dies. The condition can be disabling, causing severe headaches, nausea and vomiting, cognitive problems and neural dysfunction. A variety of medications have been used to manage symptoms such as steroids and an "off label" combination of vitamin E and pentoxifylline but currently there is no approved cure. A joint... FULL STORY
Tags: Research

Moliterno Named Editor of JACC: Cardiovascular Interventions

Posted: 1/12/2017
The American College of Cardiology has named Gill Heart Institute's Dr. David J. Moliterno, the new editor-in-chief of JACC: Cardiovascular Interventions. Moliterno is the Jack M. Gill Chair and professor of the Department of Internal Medicine at the University of Kentucky. He is also a member of the interventional cardiology faculty at the UK Gill Heart Institute. He has been involved with numerous investigational studies in cardiovascular medicine over the last two decades, with a primary research interest in acute coronary syndromes. “Interventional cardiology is an ever-growing and exciting subspecialty in cardiovascular medicine that is essential to treating... FULL STORY
Tags: Research

New Study Shows Promise for Repurposing Anti-Malarial Drug for Cancer

Posted: 1/10/2017
A new study by University of Kentucky Markey Cancer Center researchers shows that chloroquine – a drug currently used to treat malaria – may be useful in treating patients with metastatic cancers. Published in Cell Reports, the study showed that chloroquine induced the secretion of the tumor suppressor protein Par-4 in both mouse models and in cancer patients in a clinical trial. Secreted Par-4 is essential for tumor cell death and the inhibition of tumor metastasis. Chloroquine induces Par-4 secretion via the classical secretory pathway that requires activation of p53 (a mutation of the p53 protein, or disturbances in the pathways that signal to p53, is common in... FULL STORY
Tags: Markey Cancer Center, Research

Tindall-Staton Finds Passion in Research Close to Her Heart

Posted: 1/9/2017
Michele Staton-Tindall grew up in rural Appalachia during a time when people felt so safe they didn’t even lock their doors at night. The ensuing drug epidemic that now ravages her former home has dramatically impacted the lives of the Appalachian people and broken that sense of security.Staton-Tindall, an associate professor in the  Department of Behavioral Science at the University of Kentucky's College of Medicine, and a faculty associate at the Center on Drug and Alcohol Research, has made it her mission to make a positive difference in the Appalachian area, particularly for women in the criminal justice population who have fallen prey to... FULL STORY
Tags: Research, Behavioral Science, Faculty

Daugherty is Editor-in-Chief of American Heart Association Journal for

Posted: 1/4/2017
Alan Daugherty, senior associate dean for research at the University of Kentucky College of Medicine, was recently approved to renew his contract as editor-in-chief of Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association (ATVB) for a second five-year term. ATVB is one of the five core journals of the American Heart Association. As editor of ATVB, Daugherty’s primary focus is on publishing the most important new research studies related to a spectrum of vascular diseases. “We’re also committed to presenting fair and balanced reviews of critical issues in the subject areas we cover,” he said. Daugherty also serves as director... FULL STORY
Tags: Faculty, Research, Cardiovascular, Publications

Alzheimer's Association Awards $1 Million Grant to UK Sanders-Brown

Posted: 12/9/2016
Linda Van Eldik, director of the University of Kentucky Sanders-Brown Center on Aging, was awarded a "Part the Cloud" translational research grant from the Alzheimer's Association. This two-year, $997,738 grant will fund early clinical trials for a promising new treatment for Alzheimer's disease. Currently, Van Eldik’s team is exploring brain inflammation's role in nerve cell damage as a first step in identifying opportunities to suppress detrimental inflammatory molecules. "Brain inflammation is now recognized as an important driver of neurodegenerative disease progression and we desperately need new selective anti-inflammatory drugs to be tested in humans," said... FULL STORY
Tags: Alzheimer's research, Research