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NIH Requests Input Related to Sex As a Variable in Biomedical Research

Posted: 9/30/2014

[From the NIH Website] 

Request for Information (RFI): Consideration of Sex As a Biological Variable in Biomedical Research

Notice Number: NOT-OD-14-128

Key Dates
Release Date: September 11, 2014
Response Date:  October 13, 2014

Related Announcements
None

Issued by
National Institutes of Health (NIH)

Purpose

Background

In a May 14, 2014, Nature commentary (see Nature. 2014 May 15;509(7500):282-3.), NIH leadership stated an intention to develop and implement policies requiring applicants to consider sex as a biological variable in the design and analysis of NIH-funded research involving animals and cells.  Although we have made major progress in achieving balance of sex in human studies — women now account for roughly half of the participants in NIH-funded clinical trials — we have not seen a similar pattern in biomedical research.  Animal studies have typically focused on males, and investigators studying cell models have often not reported the sex of the individual from which the cells were obtained.  Even if both sexes are included in a study design, resulting data may not be analyzed or disaggregated by sex. The failure to consider sex as a variable may... FULL STORY

 

UK Researcher Earns NIH Funding to Expand Gender-Based Studies on

Posted: 9/30/2014
In her research, Sarah D'Orazio, associate professor in the University of Kentucky Department of Microbiology, Immunology and Molecular Genetics, investigates why some people get sicker than others after ingesting the foodborne bacterial pathogen Listeria monocytogenes. Using a mouse model, her research team observed that a subset of mice most susceptible to the dangerous bacteria share one common... FULL STORY
Tags: Research, NIH Award, Microbiology
 

Fourth Annual Markesbery Symposium Features Latest Research on the

Posted: 9/30/2014
The Sanders-Brown Center on Aging at the University of Kentucky will hold its fourth annual Markesbery Symposium on Aging and Dementia on Friday and Saturday, Nov. 21-22. The Markesbery Symposium is named in honor of the late Dr. William R. Markesbery, founder and long-time director of the UK Sanders-Brown Center on Aging and an internationally renowned expert on aging and dementia. More than 5... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Research
 

UK Study Identifies Molecule That Induces Cancer-killing Protein

Posted: 9/15/2014 - Tags: Research, Radiation Medicine
A new study by University of Kentucky researchers has identified a novel molecule named Arylquin 1 as a potent inducer of Par-4 secretion from normal cells. Par-4 is a protein that acts as a tumor suppressor, killing cancer cells while leaving normal cells unharmed. Normal cells secrete small amounts of Par-4 on their own, but this amount is not enough to kill cancer cells. Notably, if Par-4 secretion is suppressed, this leads to tumor growth. Published in "Nature Chemical Biology," the UK study utilized lab cultures and animal models to show that low levels of Arylquin 1 induced Par-4 secretion without causing harm to the producer cells. Additionally,... FULL STORY

Twitter Chat Offers Insight on Participating in Health Research

Posted: 9/15/2014 - Tags: Research, Clinical, Center for Clinical and Translational Science, Barnstable Brown Kentucky Diabetes and Obesity Center
Did you know that you can help others by participating in research? Health-focused research affects every aspect of our lives, from the medications we take to the health of our environment. Researchers are working hard to identify new treatments and strategies to improve the health of our communities, but research needs healthy volunteers and volunteers with medical conditions in order to succeed. Participating in research is a safe, easy way for you to give back to your community and give hope for the future while learning more about your own health. Find out how you can participate in research during the University of Kentucky's next #AskACat Twitter chat,... FULL STORY

Meyer-van der Westhuyzen Study of Oxidized LDL Shows Early Promise For

Posted: 9/4/2014 - Tags: Lipid Research, Research, Saha Cardiovascular Research Center
A team of investigators has made a thought-provoking discovery about a type of cholesterol previously believed to be a "bad guy" in the development of heart disease and other conditions. Jason Meyer, a University of Kentucky M.D.-Ph.D. candidate, worked with Deneys van der Westhuyzen, a professor in the departments of Internal Medicine and Molecular and Cellular Biochemistry, to study the role oxidized LDL plays in the development of plaque inside artery walls. According to Meyer, the medical research community has traditionally believed that oxidized LDL plays a pivotal role in that process. "Oxidized LDL moves rapidly into arterial walls and engorges them... FULL STORY

MRI Used to Study Possible Therapies for Adult Congenital Heart Disease

Posted: 8/14/2014 - Tags: Research, Congenital Heart Disease, Cardiology
Studies show that adults who received corrective surgery for the most common serious form of congenital heart disease as infants are susceptible to heart failure in adulthood. Researchers at the University of Kentucky are using magnetic resonance imaging (MRI) technology to better understand the cause of heart failure in these patients, with the goal of eventually developing new therapies to reduce mortality. The team, led by University of Kentucky professor Dr. Brandon Fornwalt, recently published their findings in an article appearing in the European Heart Journal titled, "Patients with Repaired Tetralogy of Fallot Suffer From Intra- and Inter-Ventricular Cardiac... FULL STORY

Research Investigates Another "Kentucky Ugly"

Posted: 8/13/2014 - Tags: Behavioral Science, Research
From the New York Times to visits from the director of the Centers of Disease Control and Prevention, health disparities in Appalachia are receiving a lot of attention, and for good reason. The list is sadly familiar: life expectancy in the region is about five years lower than national averages; rates of cancer, cardiovascular disease, stroke, obesity, diabetes, and unintentional injury are among the very worst in the country; and myriad socioeconomic and geographic barriers limit access to health insurance and care. Former University of Kentucky President Lee Todd Jr. famously referred to these measures as the "Kentucky uglies." Kentucky has yet another "ugly,"... FULL STORY

Following a Scientific Trail

Posted: 8/12/2014 - Tags: Research, Biochemistry
University of Kentucky associate professor Dr. Matthew Gentry, a biochemist who studies the very basic makeup of living things, can count very few "Eureka!" moments in his scientific career. One of those moments occurred while he was studying the genetic mutation associated with Lafora's disease, a type of epilepsy that inevitably causes death from neurodegeneration early in life. He was conducting post-doctoral research at University of California-San Diego to determine what happens within the cells of children born with Lafora's disease. He was examining the role of the protein laforin, the mutation that causes the disease. He and a colleague performed a series of... FULL STORY

Yasuma Receives Fight for Sight Postdoctoral Research Award

Posted: 7/28/2014 - Tags: Ophthalmology and Visual Sciences, Awards and Recognition, Research
Tetsuhiro Yasuma, postdoctoral Fellow in the Department of Ophthalmology and Visual Sciences at the University of Kentucky College of Medicine, has been selected to receive the 2014 Fight for Sight Postdoctoral Award from Fight for Sight, a non-profit organization that promotes eye research by providing pilot funding to promising new researchers. Yasuma received training in biomedical research as an undergraduate student in Japan and general ophthalmology and surgery in graduate school. Yasuma joined the Ambati lab at UK in 2012. His research focuses on finding treatment for dry Age-Related Macular Degeneration (AMD), the form of AMD that affects the majority of AMD... FULL STORY

Sanders-Brown Research Presentation Garners Hirano Prize

Posted: 7/22/2014 - Tags: Research, UK Sanders-Brown Center on Aging, Awards and Recognition
Dr. Peter T. Nelson of the Sanders-Brown Center on Aging (SBCoA) at the University of Kentucky, and David Fardo of UK's Department of Biostatistics, have been awarded the 2014 Asao Hirano Prize from the American Association of Neuropathologists (AANP) for the best paper presented on neurodegenerative diseases at its annual meeting in Portland, Oregon, last month. The team's research, titled "Hippocampal Sclerosis of Aging (HS-A): Connecting Genomics and Other Risk Factor Data," compared 363 persons with autopsy-proven HS-A to a control group of 2,303 other individuals in an attempt to identify genetic predisposition to HS-A in what's called a genome-wide association... FULL STORY

New UK Study Helps Scientists Understand Melanoma Development

Posted: 7/15/2014 - Tags: Markey Cancer Center, Research, Clinical, Melanoma
A new study by University of Kentucky researchers shows how a genetic defect in a specific hormonal pathway may make people more susceptible to developing melanoma, the deadliest type of skin cancer. Fair-skinned people who tend to burn (rather than tan) from sun exposure have a much higher risk for melanoma than darker-skinned people. On the surface, it appears that the amount of melanin, the natural substance in the skin that determines pigment and acts as the skin's "natural sunscreen," would be the only determinant of melanoma risk. However, the truth is more complicated. Published in Molecular Cell, the study looked at the role of the melanocortin1 receptor... FULL STORY

Three Researchers from the Sanders-Brown Center on Aging Awarded Bright

Posted: 7/14/2014 - Tags: Research, UK Sanders-Brown Center on Aging, Alzheimer's research
The Bright Focus Foundation has announced that three different researchers from the Sanders-Brown Center on Aging at the University of Kentucky have received Bright Focus grants for 2014. Professor Steve Estus and associate professors Harry LeVine and Paul Murphy were each recognized for their work on Alzheimer's disease. "Only 25 Bright Focus grants are awarded worldwide each year, so it's an achievement to get one. But three Bright Focus grants in a single year is truly exceptional," said Dr. Michael Karpf, UK HealthCare's executive vice president of health affairs. "These awards are an appropriate reflection of Sanders-Brown's international reputation for... FULL STORY

Alzheimer's With Cerebrovascular Disease Compounds Cognitive Decline

Posted: 7/8/2014 - Tags: UK Sanders-Brown Center on Aging, Research
Researchers from the Sanders-Brown Center on Aging at the University of Kentucky have been able to confirm anecdotal information on patients with both Alzheimer's disease (AD) and cerebrovascular disease (CVD) using mouse models in two different studies. The findings of these two studies, which were recently published in Acta Neuropathologica and Alzheimer's Research... FULL STORY

Guo Lab Reports Finding of Revolution Biomotors in Many Bacteria and

Posted: 6/30/2014 - Tags: Research, Biomedical
Scientists at the University of Kentucky, led by nano-biotechnologist Peixuan Guo, have made some critical discoveries over the past year into the operation of biomotors, the molecular machines used by viruses and bacteria in the packaging of DNA. Biomotors function similarly to mechanical motors but on a nano-scale. Last year, Guo's team reported the discovery of a new, third class of biomotor, unique in that it uses a "revolution without rotation" mechanism. Rotation is the turning of an object around its own axle, as the Earth does every 24 hours. Revolution is the turning of an object around a second object, as the Earth does around the sun. Recently, Guo's... FULL STORY
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