Proposed Clinical Trial Could Change the Game for Deadly Type of Breast

Posted: 11/3/2016 - Tags: Research, Markey Cancer Center, Clinical Trials
University of Kentucky Markey Cancer Center Oncologist Dr. Edward Romond spent his career at UK treating and studying breast cancer, even leading major Phase 3 clinical trials on the breast cancer drug trastuzumab in the early 2000s. Commonly known as Herceptin, this drug became a standard of care for patients with HER2-positive breast cancer.Though he retired from practice last year, Romond continues to work part-time with the research team at Markey, this time pushing toward a cure for a different, more deadly, type of breast cancer. "Breast cancer, we now recognize, is at least five different disease that are completely different from each other," Romond said. "... FULL STORY

Getchell Memorial Award Honors Graduate Scientist's Persistence in

Posted: 11/3/2016 - Tags: Awards and Recognition, Research
The second annual Thomas V. Getchell, Ph.D., Memorial Award for excellence in grant writing was presented to Jenna Gollihue, a graduate student in the University of Kentucky Spinal Cord and Brain Injury Research Center, on Nov. 2. The award honors the memory of Getchell, a former professor of physiology in the UK Department of Physiology who encouraged researchers to improve grant writing skills to acquire research funding. The award supports a travel stipend for a student participating in the annual Grant Writing Workshop. Getchell founded the Grant Writing Workshop in 2005 with a vision to provide proactive, individualized mentoring to medical, doctoral and post... FULL STORY

UK Receives $19.8 Million Clinical and Translational Science Award

Posted: 10/26/2016 - Tags: Research, NIH Award
The University of Kentucky Center for Clinical and Translational Science (CCTS) announced today that it received a four-year, $19.8 million Clinical and Translational Science Award (CTSA) from the National Center for Advancing Clinical and Translational Sciences at the National Institutes of Health. CTSA grants support innovative solutions to improve the efficiency, quality, and impact of translating scientific discoveries into interventions or applications that improve the health of individuals and communities.UK officials were joined by U.S. Senate Majority Leader Mitch McConnell and Congressman Andy Barr for the announcement.This is the... FULL STORY

Nika Larian Maps Interactions between Nutrients, Exposures & Diabetes

Posted: 10/20/2016 - Tags: Research
Nika Larian, a PhD student in Lisa Cassis's lab at the UK Superfund Research Center, is studying the aryl hydrocarbon receptor, or AHR, a transcription factor with roles in drug metabolism and detoxification. She explains that if you knock out AHR in the fat tissue of mice, you can prevent the development of polychlorinated biphenyl (PCB)-induced diabetes. PCBs are toxins that are present in the environment and have been linked to type 2 diabetes."I'm investigating natural components of the microbiome that are influenced by a high-fat diet, and may also be altered by exposure to PCBs. The microbiome is influenced by what we eat, including the consumption of a high-fat... FULL STORY

VIDEO: What Motivates UK Vice President for Research Lisa Cassis?

Posted: 10/14/2016 - Tags: Research
When Lisa Cassis isn’t in her cardiovascular research lab, you’ll find her leading the research enterprise at the University of Kentucky. How does the UK researcher balance her time in the lab and in the office? What motivates her each morning? Watch the video below to find out what keeps Cassis motivated and why a special talent is her favorite way to relax after a long day of work.About Lisa CassisLisa Cassis earned a bachelor's degree in pharmacy and a doctoral degree in pharmacology from West Virginia University, followed by postdoctoral positions as an Alexander Von Humboldt Fellow in Pharmacology at Wurzburg, West Germany, and within the... FULL STORY

NIDA Director Examines Scope of Substance Abuse Research Undertaken at UK

Posted: 10/10/2016 - Tags: Research, CDAR
Multidisciplinary researchers unified by a mission to develop therapies, interventions and evidence-based solutions to substance use disorders delivered snapshots of their work to National Institute on Drug Abuse director Dr. Nora Volkow on Oct. 7. The series of presentations and roundtable discussion concluded Volkow’s two-day tour of Kentucky. Volkow traveled to Kentucky with the purpose of better understanding the gravity of the opioid epidemic and learn about projects underway to resolve the state’s austere substance abuse problems. Researchers from the University of Kentucky Center on Drug and Alcohol Research (CDAR), UK College of Pharmacy, and UK College... FULL STORY

UK Center for Health Services Research Collaborates to Study Chronic

Posted: 10/4/2016 - Tags: Center for Health Services Research, Research
Multiple Chronic Conditions (MCC) affects one in four Americans overall and about three in four Americans age 65 and older. While health care aims to relieve suffering and alleviate burden, it sometimes makes burdensome demands of patients. Patients must invest capacity — time, emotion, and attention — to do the work of being a patient, which competes with other important tasks in their lives.For patients with MCC, a shift in practice is required: one that focuses on each patient’s health situation and on the limited capacity patients have to advance their health situation, while still pursuing joyful lives.The University of Kentucky Center for Health Services Research... FULL STORY

Sanders-Brown Research Hints at Underlying Cause for Alzheimer's Drug

Posted: 10/3/2016 - Tags: Research, Alzheimer's disease, Alzheimer's research, UK Sanders-Brown Center on Aging
Because Alzheimer’s disease (AD) is the leading cause of dementia, many people use the two terms interchangeably. But inadequate blood flow to the brain due to microinfarcts, mini-strokes, or strokes is a hallmark of a disease called Vascular Cognitive Impairment and Dementia (VCID). VCID is the second most common cause of dementia, and the two are not mutually exclusive – researchers estimate that 40-60% of Alzheimer’s disease patients also have VCID. A paper recently published in the Journal of Neuroscience by Donna Wilcock, PhD, of the University of Kentucky Sanders-Brown Center on Aging, reports that a certain form of immunotherapy targeted to Alzheimer's... FULL STORY

Symposium Showcases Clinical and Translational Research in the

Posted: 9/29/2016 - Tags: Neurology, Research, Kentucky Neuroscience Institute
More than 200 scientists and clinical investigators gathered last week to share insights and learn more about translational and clinical neuroscience research underway at the University of Kentucky. The 2016 Clinical-Translational Neuroscience Research Symposium, hosted by the Kentucky Neuroscience Institute, featured nearly 100 poster and oral presentations focused on the latest scientific advances in a wide variety of topics related to the neurosciences being conducted by UK research groups. According to Dr. Larry B. Goldstein, chair of the UK Department of Neurology and KNI co-director, the symposium's goal was to provide a venue for “showcasing the incredible... FULL STORY

6th Annual Markesbery Symposium Set for Nov. 4-5

Posted: 9/21/2016 - Tags: UK Sanders-Brown Center on Aging, Research, Alzheimer's research
University of Kentucky Sanders-Brown Center on Aging (SBCoA) is hosting its sixth annual Markesbery Symposium on Aging and Dementia on Nov. 4-5. This two-day program will offer sessions for both the scientific and community audiences. Clinicians and researchers from UK and other institutions will come together to share current findings, trends and the latest updates on dementia and aging disorders, particularly as related to Alzheimer’s disease. The Markesbery Symposium is in honor of the late Dr. William R. Markesbery, the founder and long-time director of the UK Sanders-Brown Center on Aging and an internationally renowned expert on aging and dementia. On... FULL STORY

UK Sanders-Brown Center on Aging Receives $8.25 Million to Continue

Posted: 9/1/2016 - Tags: Research, UK Sanders-Brown Center on Aging, Grants and Funding
The University of Kentucky Sanders-Brown Center on Aging Alzheimer's Disease Center (ADC) has been awarded an $8.25 million, five-year grant from the National Institutes of Health (NIH) to continue and further research and clinical initiatives geared toward treating Alzheimer's disease. Currently, only 30 designated Alzheimer's Disease Centers exist in the U.S. In 1985, Sanders-Brown was among the first 10 ADCs funded by the NIH and has been continuously funded since the designation was launched. UK is one of an elite group of 21 universities in the nation to house a trifecta of nationally accredited research institutions, including a National Cancer Institute-... FULL STORY

Dubey Receives Macular Degeneration Scholar Award

Posted: 8/19/2016 - Tags: Ophthalmology and Visual Sciences, Research
Sushil Kumar Dubey, postdoctoral fellow in the Department of Ophthalmology and Visual Sciences at the University of Kentucky College of Medicine, has been selected for the 2016 Charles D. Kelman, MD Scholar Award from the International Retina Research Foundation (IRRF). The Charles D. Kelman, MD Scholar Award is one of three IRRF awards that have been designated in honor of individuals who played a critical role in the development of the International Retinal Research Foundation and are meant to serve as a memorial to their efforts. The IRRF awards were established to provide salary and research support in the amount of $35,000 per year for a postdoctoral scholar... FULL STORY