Sci-Fi to Reality: Superpowered Salamander May Hold Key to Human

Posted: 1/24/2019
Regeneration is one of the most enticing areas of biological research. How are some animals able to regrow body parts? Is it possible that humans could do the same? If scientists could unlock the secrets that confer those animals with this remarkable ability, the knowledge could have profound significance in clinical practice down the road.  Scientists at the University of Kentucky have taken this concept one step closer to reality, announcing today that they have assembled the genome of the axolotl, a salamander whose only native habitat is a lake near Mexico City.Axolotls have long been prized as models for... FULL STORY
Tags: scobirc, Research

Study Links Smoking During Pregnancy With Increase in Obesity Later in

Posted: 1/16/2019
University of Kentucky researchers have identified a potential cellular mechanism that connects a mother's smoking while pregnant with an increased risk in the offspring's obesity later in life. Obesity is considered an epidemic in the U.S., with nearly 35 percent of adults and 20 percent of children six to 19 years old deemed obese. Obesity is a serious economic burden as well: more than $150 billion is spent annually on obesity-related healthcare costs in the U.S. alone."It has been consistently shown that mothers who smoke during pregnancy confer increased risk of obesity to their baby, but the mechanisms responsible for this increased risk are not... FULL STORY
Tags: OB, Research

UK Study Shows Promise Toward Prevention of Melanoma

Posted: 1/15/2019
In a study published in the Journal of Biological Chemistry, a team of University of Kentucky researchers led by Stuart Jarrett, Ph.D., and Dr. John D’Orazio have discovered specific protein interactions that may help cells resist ultraviolet (UV) damage and carcinogenesis.The UK study focused on the role of a cell receptor found in melanocytes known as the melanocortin 1 receptor (MC1R). This receptor helps cells produce melanin pigments, which get deposited in the skin and act as “built-in sunblock” to protect the skin from harmful UV rays in sunlight. The MC1R also protects melanocytes by increasing their ability to repair DNA damage caused by UV exposure –... FULL STORY
Tags: Markey Cancer Center, Research

Daret St. Clair Receives Lifetime Achievement Award from International

Posted: 11/27/2018
University of Kentucky Markey Cancer Center researcher Daret St. Clair, Ph.D., has been named the 2018 Lifetime Achievement Award Recipient from the Society for Redox Biology and Medicine (SfRBM). St. Clair received the award and gave a feature lecture at the SfRBM’s 25th Annual Conference in Chicago earlier this month.St. Clair's career is marked by her seminal work on the role of manganese superoxide dismutase (MnSOD) in cancer development and therapy. Her research has resolved long-debated questions about MnSOD expression in cancer and has demonstrated that the presence of MnSOD inversely regulates the induction and progression of cancer.Her... FULL STORY
Tags: Faculty, Research

UK Biochemist Recognized for Work in FUS-ALS

Posted: 11/21/2018
Researchers at the University of Kentucky have discovered new biological processes by which mutations in the FUS gene cause neurodegeneration in amyotrophic lateral sclerosis (ALS).FUS is a DNA and RNA binding protein that resides predominantly in the nucleus and appears to play a role in DNA repair and RNA metabolism. In contrast, ALS-related mutations cause the protein to accumulate in the cytoplasm, which can contribute to inclusion bodies – the pathological hallmarks of disease – and neurotoxicity.A group led by Haining Zhu, a professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky, discovered that ALS-causing... FULL STORY
Tags: Biochemistry, Research

Research Identifies Potential Predictors of Vascular Cognitive Impairment

Posted: 11/7/2018
Research at the University of Kentucky Sanders-Brown Center on Aging has identified two potential ways to predict vascular cognitive impairment and dementia (VCID) – the second leading cause of dementia behind Alzheimer's disease.VCID results from injuries to the vessels that supply blood to the brain, including mini-strokes, and/or by risk factors that are also known to cause heart disease or stroke:  high cholesterol, smoking, high blood pressure and/or diabetes. About 10 percent of all dementia cases are caused by VCID, while Alzheimer's accounts for between 60 and 80 percent. Sometimes Alzheimer's and VCID can occur simultaneously, which is... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Research

New Grant Provides Retinopathy Screenings for Diabetics

Posted: 10/24/2018
Diabetes is a complex condition that requires patients to check in with providers across a number of specialties. Multiple appointments with practitioners can mean endless rounds of scheduling, traveling and follow-ups. Many patients don't have the flexibility to take off work, the means to travel, or access to education materials to help them manage their condition. But thanks to a new grant secured by UK HealthCare's CE Central and their partners at DKBmed, vital screenings for diabetic retinopathy will be conducted by the patient's primary care provider.Starting in March 2019, diabetic patients can receive retinopathy screenings at their primary care clinic.... FULL STORY
Tags: Ophthalmology, Research

UK Research Links Signaling Pathways to Combatting Fetal Alcohol Syndrome

Posted: 10/19/2018
Fetal alcohol spectrum disorders are an array of conditions that can occur in a person whose mother consumed alcohol during pregnancy. Fetal alcohol syndrome (FAS), the most severe of these conditions, often results in physical abnormalities, behavioral development issues and intellectual disabilities.  Researchers at the University of Kentucky College of Medicine have discovered that targeting a specific signaling pathway could potentially provide a new therapeutic avenue for treating FAS. Kai Zhang, a doctoral student in the Department of Pharmacology and Nutritional Sciences, has worked as a member of  Professor Jia Luo’s... FULL STORY
Tags: Research, Pharmacology and Nutritional Sciences


Posted: 10/18/2018
The NIH Center of Biomedical Research Excellence (COBRE) on Obesity and Cardiovascular Diseases, in collaboration with the Center for Clinical and Translational Sciences (CCTS) announce the availability of limited funds to support pilot projects focused on research examining obesity-associated diseases. Emphasis for support will be placed on pilot projects that examine the relationship between obesity and cardiovascular diseases, type 2 diabetes, cancer, and neurodegenerative diseases.  These pilot grants are intended to assist investigators new to this area of research to generate sufficient data to be competitive for extramural funding.Funding Amount:Individual... FULL STORY
Tags: Research, Grants and Funding, cardiovascular disease

Register for Markesbery Symposium's Scientific, Community Sessions

Posted: 10/4/2018
Alzheimer's disease wreaks emotional havoc on patients, who are robbed of their memories, their dignity and their lives. It’s financially devastating as well: care for Alzheimer's patients is predicted to top $1 trillion by about the time children born today are having children of their own.Almost six million Americans are living with Alzheimer's disease, which likely means that all of us know someone whose lives have been touched — directly or indirectly — by dementia. And since that number is expected to rise to nearly 14 million by 2050, Alzheimer's will likely hit closer to home for many of us. The UK Sanders-Brown Center on Aging, a world leader in... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Alzheimer's research, Research

Two Sanders-Brown Studies Show Connection Between Diet, Cognitive Function

Posted: 10/2/2018
We've all experienced a "gut feeling" — when we know deep down inside that something is true. That phenomenon and others, aptly describe what scientists have now demonstrated: that the gut and the brain are more closely connected than we once thought, and in fact the health of one can affect the other.Capitalizing on this relatively new scientific concept, Ai-Ling Lin, and her colleagues at the University of Kentucky Sanders-Brown Center on Aging, have published two studies that demonstrate the effect of diet on cognitive health in animals.The first, in Scientific Reports, demonstrated that neurovascular function improved in mice who followed a... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Research, Alzheimer's disease

Cardiovascular Research Day Features Science From Regional, National

Posted: 9/26/2018
Last week, more than 200 faculty, staff, and trainees from across the nation attended the Gill Heart & Vascular Institute's Cardiovascular Research Day to share the latest research on cardiovascular health. The event, in its 21st year, showcased the research of postdoctoral fellows, students, and faculty, much of it focused on the prevention or reversal of cardiovascular diseases, including heart attacks and strokes. This year’s event featured two judged poster sessions; four trainee presentations; a research blitz of one-minute research presentations and faculty oral presentations from distinguished alumni Gregory Graf, PhD, Professor in the University of... FULL STORY
Tags: Saha Awards, Research