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UK Researchers Point to Impact of Combined Brain Injury and PTSD in War Veterans

Posted: 12/22/2014

The U.S. Department of Defense identifies mild traumatic brain injury, or mTBI, as one of the signature injuries impacting veterans who served in Iraq and Afghanistan.

Often associated with the blast of an improvised explosive device (IED) in the field, an mTBI is commonly diagnosed in concurrence with posttraumatic stress disorder, a separate condition triggered by the traumatic event. A recent study suggests that 12 to 16 percent of all veterans involved in the Iraqi conflict have a history of mTBI and an estimated 13 to 17 percent of veterans return with a diagnosis of PTSD resulting from an injury. One-third of all veterans with a TBI also suffer from PTSD.

Since the time both conflicts began, medical researchers have studied the short- and long-term psychological and neuropsychological effects of PTSD and mild TBI as independent conditions. Recently, researchers at the University of Kentucky published findings from a collaborative, multi-site study considering the collective, as well as individual, effects of mTBI and PTSD on psychological and cognitive functioning.

The results, which are scheduled to appear in The Journal of Neurotrauma, suggest veterans suffering from both conditions have poorer cognitive and psychological outcomes than veterans... FULL STORY

Tags: Research, Rehabilitation Medicine
 

94 Year-Old Lexington Woman Gives Back as Research Volunteer

Posted: 12/19/2014
On Dec. 2, a very special group of people gathered to celebrate a very special gift. "Participation in clinical trials is a truly noble act, and we consider the people who volunteer for research part of our family," says Dr. Gregory Jicha, a professor at the University of Kentucky's Sanders-Brown Center on Aging. "So it's natural that we would gather at the holidays to share a little joy and... FULL STORY
Tags: Research, UK Sanders-Brown Center on Aging, Clinical Trials
 

OPSA Provides Update on Federal Uniform Guidance

Posted: 12/16/2014
The PowerPoint from the University’s update meeting held on December 11, 2014, can be found below.  Pay particular attention to the section on inclusion of “Administrative and Clerical Salaries,” as this language has already been incorporated into the NIH SF424 R&R  Application Guide (see page I-96). 
 

UK Physiologist Leads Team that Identifies Receptors Activated by Odors

Posted: 11/26/2014 - Tags: Research, Physiology
A group of physiologists led by University of Kentucky’s Tim McClintock have identified the receptors activated by two odors using a new method that tracks responses to smells in live mice. Their research was published in the latest edition of The Journal of Neuroscience. Using a fluorescent protein to mark nerve cells activated by odors, McClintock and his colleagues identified receptors that allow mouse nerve cells to respond to two odors: eugenol, which is a component of several spices, most notably cloves, and muscone, known as musk. "This new method could help us understand how these receptors allow mice, and eventually humans, to detect and... FULL STORY

Markesbery Symposium Presents Latest Research on Aging and Dementia

Posted: 11/25/2014 - Tags: UK Sanders-Brown Center on Aging, Alzheimer's research, Research
More than 450 scientists, researchers and laypeople converged on Lexington last week for the fourth annual Markesbery Symposium on Aging and Dementia, hosted by the University of Kentucky's Sanders-Brown Center on Aging. The two-day program offered sessions for both scientific and community audiences to share current findings, trends and the latest updates on dementia and aging disorders, particularly Alzheimer's disease. The scientific session and poster presentations were held on Friday, Nov. 21, at the UK Albert B. Chandler Hospital. This session featured speakers William E. Van Nostrand, Ph.D., of Stony Brook University, and Dr. Steven M. Greenberg of... FULL STORY

'Three Minute Thesis' Prepares Students to Present Research

Posted: 11/21/2014 - Tags: Research
Four students seeking their master's degrees and five students doctoral programs competed last week in an event designed to prepare them for presenting research. The "Three Minute Thesis" event, hosted by the UK Graduate School and the Graduate Student Congress, is a research communication initiative requiring graduate students to speak succinctly and engagingly about their current research to a nonspecialist audience. It provides students with the opportunity to practice presenting their work, and to receive feedback from a panel of judges. A preliminary competition took place during the previous week, culminating with a final competition Tuesday, Nov. 11.... FULL STORY

HIV/AIDS Drugs Could Be Repurposed to Treat Age-Related Macular

Posted: 11/20/2014 - Tags: Ophthalmology, Ophthalmology and Visual Sciences, Research
A landmark study published today in the journal Science by an international group of scientists, led by the laboratory of Dr. Jayakrishna Ambati, professor and vice chair of the Department of Ophthalmology... FULL STORY

New Alzheimer’s-Related Memory Disorder Identified

Posted: 11/15/2014 - Tags: Research, Pathology, Alzheimer's research, UK Sanders-Brown Center on Aging
A multi-institutional study has defined and established criteria for a new neurological disease closely resembling Alzheimer’s disease called primary age-related tauopathy (PART). Patients with PART develop cognitive impairment that can be indistinguishable from Alzheimer’s disease, but they lack amyloid plaques. Awareness of this neurological disease will help doctors diagnose and develop more effective treatments for patients with different types of memory impairment.  The study, co-led by Dr. Peter T. Nelson of the University of Kentucky's Sanders-Brown Center on Aging, and Dr. John F. Crary of Mount Sinai Hospital, was published in the... FULL STORY

UK Researcher Leads Global Team of Scientists Exploring the Processes that

Posted: 11/10/2014 - Tags: Research
During a woman's menstrual cycle, ovulation is the critical mid-point when an egg is released and fertilization can occur. Women's health providers have long understood that a woman's best chances of becoming pregnant are around the time of ovulation. But researchers are still learning about the physiological triggers that initiate this natural process in humans and other mammals. Researchers at the University of Kentucky are leading a project that recently received $6 million in funding from the National Institutes of Health (NIH) to explore the ovulatory process, or the series of physiological events that result in the release of an egg from the ovaries. A... FULL STORY

UK Study Published in PNAS Reveals Mechanisms of Dry Age-Related Macular

Posted: 11/4/2014 - Tags: Research, Ophthalmology, Ophthalmology and Visual Sciences
University of Kentucky researchers led by Dr. Jayakrishna Ambati, professor and vice-chair in the Department of Ophthalmology and Visual Sciences at the University of Kentucky, have made revealing discoveries about the precise mechanisms of retinal pigmented epithelium (RPE) death in the late stages of age-related macular degeneration (AMD). The findings were released last week in the Proceedings in the National Academy of Sciences (PNAS). Geographic atrophy, an advanced form of dry AMD characterized by death of the RPE, causes untreatable blindness in millions worldwide. Previous studies from the Ambati lab reported in the journals Nature and Cell showed that RPE... FULL STORY

Annual Gill Cardiovascular Research Day Features Latest Research in

Posted: 10/31/2014 - Tags: Research, Cardiovascular, Saha Cardiovascular Research Center
On Oct. 17, the Lexington Convention Center teemed with more than 200 students and scientists sharing their latest research on cardiovascular health for the 17th annual Gill Heart Institute Cardiovascular Research Day. Nigel Mackman, Ph.D., director of the McAllister Heart Institute at the University of North Carolina at Chapel Hill, presented "Hematosis, Thrombosis and Immunity," demonstrating the diverse roles of hemostasis and thrombosis in cardiovascular diseases, cancers and infections. Kathryn J. Moore, Ph.D., professor of medicine and cell biology at New York University's Langone Medical Center, presented "Mechanisms of Chronic Inflammation in Cardiometabolic... FULL STORY

UK Researcher Awarded $100K Grant To Study Protein Associated with

Posted: 10/14/2014 - Tags: Research, UK Sanders-Brown Center on Aging, Alzheimer's disease
The Alzheimer’s Association has awarded a $100,000 New Investigator Research Grant to Jose Abisambra, assistant professor at the University of Kentucky's Sanders-Brown Center on Aging (SBCoA), to study a brain protein that becomes abnormally modified in the course of developing Alzheimer's disease. The New Investigator Research Grant program is part of the Alzheimer’s Association’s effort to increase the number of scientists conducting Alzheimer’s research by supporting early-career development that will lay the groundwork for future research grants. Only investigators with fewer than 10 years of research experience are eligible for these particular grants. "This... FULL STORY

UK Researcher Earns NIH Funding to Expand Gender-Based Studies on

Posted: 9/30/2014 - Tags: Research, NIH Award, Microbiology
In her research, Sarah D'Orazio, associate professor in the University of Kentucky Department of Microbiology, Immunology and Molecular Genetics, investigates why some people get sicker than others after ingesting the foodborne bacterial pathogen Listeria monocytogenes. Using a mouse model, her research team observed that a subset of mice most susceptible to the dangerous bacteria share one common trait: they are all female. With supplemental funding from the National Institutes of Health (NIH), D'Orazio has the resources to explore why Listeria infection affects females more severely than their male counterparts. Part of an effort to promote sex-based research,... FULL STORY

Fourth Annual Markesbery Symposium Features Latest Research on the Aging

Posted: 9/30/2014 - Tags: UK Sanders-Brown Center on Aging, Research
The Sanders-Brown Center on Aging at the University of Kentucky will hold its fourth annual Markesbery Symposium on Aging and Dementia on Friday and Saturday, Nov. 21-22. The Markesbery Symposium is named in honor of the late Dr. William R. Markesbery, founder and long-time director of the UK Sanders-Brown Center on Aging and an internationally renowned expert on aging and dementia. More than 5 million Americans have Alzheimer's disease (AD) today and millions more are affected by their role as family member, friend or caregiver to those with memory loss. The Markesbery Symposium was established to improve awareness of and education about AD and the latest... FULL STORY

UK Researcher Explores Gene's Role in Blood Clotting

Posted: 9/19/2014 - Tags: Research, Biochemistry, Von Willebrand Factor
Two independent groups of researchers led by Sidney "Wally" Whiteheart, PhD, at the University of Kentucky, and Dr. Charles Lowenstein, at the University of Rochester, have published important studies exploring the role that a gene called STXBP5 plays in the development of cardiovascular disease. According to Whiteheart, previous genome-wide association studies (GWAS) identified a gene called STXBP5 as a factor that regulates a protein called Von Willebrand factor (VWF). VWF is an important contributor to normal blood clotting. When the endothelial cells that line a blood vessel are injured, VWF is released into the bloodstream, where it "collects" blood... FULL STORY
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