It’s Not Just Alzheimer’s Disease: Sanders-Brown Research Highlights Form

Posted: 6/29/2020
The long-running study on aging and brain health at the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) Alzheimer’s Disease Center has once again resulted in important new findings – highlighting a complex and under-recognized form of dementia. The work was recently published in The Journal of the American Medical Association (JAMA): Neurology. “One of the things that we’ve learned in the last decade or so is that a lot of people that we think have dementia from Alzheimer’s disease, actually don’t. There are other brain diseases that cause the same kind of symptoms as Alzheimer’s, including some that we only recently figured out existed,” said Erin... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Research

UK Ophthalmologist Writes Article Highlighting Limited and Inconsistent

Posted: 6/25/2020
Dr. Daniel Moore, from the University of Kentucky College of Medicine’s Department of Ophthalmology and Visual Sciences, recently conducted a study looking at the frequency and use of racial and ethnic data in ophthalmology literature published throughout 2019. He wrote an article outlining his findings which was published in The Journal of the American Medical Association: Ophthalmology. Moore says the description of racial and ethnic data in human trials is relatively unregulated which can lead to confusion and inconsistent reporting. In the article, he writes, “The use of race and ethnicity in the medical literature is historically and currently controversial, with... FULL STORY
Tags: Research

Artemisia Annua Could Be Promising Treatment for COVID-19

Posted: 6/25/2020
Recent lab studies by chemists at the Max Planck Institute of Colloids and Interfaces (Potsdam, Germany) in close collaboration with virologists at Freie Universität Berlin have shown that extract from the medicinal plant Artemisia annua, also known as Sweet Wormwood, is active against SARS-CoV-2, the virus that has caused the COVID-19 pandemic. The new potential treatment has been added to the University of Kentucky’s innovative clinical trial for experimental COVID-19 therapies, which was launched by leaders from UK’s Markey Cancer Center, College of Medicine and College of Pharmacy in May. The new arms of the clinical trial will test the effectiveness of... FULL STORY
Tags: Research

Alpacas Could be the Secret Weapon Against COVID-19

 Antibodies from Big Boy, Emperor and Blue Eyes are helping UK researchers understand COVID-19 and potentially develop a treatment that could protect people from being infected. Photo by Ben Corwin, Research Communications. Posted: 6/19/2020
LEXINGTON, Ky. (June 18, 2020) — Alpacas Big Boy, Blue Eyes and Emperor may hold the key to combating COVID-19. Their antibodies could offer a defense against SARS-CoV-2, the virus that causes the disease.University of Kentucky College of Medicine researchers are using the special antibodies made by alpacas, called nanobodies, to help understand the novel coronavirus and potentially develop a treatment that could protect people from being infected. Nanobodies are smaller and more stable types of antibodies taken from the immune systems of camelids – which include camels, llamas and alpacas. Nanobodies could be more effective at fighting the disease... FULL STORY
Tags: Research, Research

UK College of Medicine, UK HealthCare Launch New START Trial to Assess

Posted: 6/17/2020
The University of Kentucky College of Medicine and UK HealthCare have launched a new clinical trial designed to assess the prevalence of COVID-19 in central and eastern Kentucky. Known as Serologic Testing to Accelerate Recovery and Transition (START), the study focuses on antibody testing to begin understanding how many people in the region may have already contracted and recovered from COVID-19. The trial is a partnership between the UK College of Medicine, UK HealthCare Infection Prevention and Control (IPAC), the UK Markey Cancer Center, and University Health Service, and is co-led by IPAC Medical Director Dr. Derek Forster and Precision Medicine Clinic Director... FULL STORY
Tags: Covid-19, Research

PILOT PROJECT FUNDING OPPORTUNITY

Posted: 6/2/2020
The NIH Center of Biomedical Research Excellence (COBRE) on Obesity and Cardiovascular Diseases, in collaboration with the Center for Clinical and Translational Sciences (CCTS) announce the availability of limited funds to support pilot projects focused on research examining obesity-associated diseases. Emphasis for support will be placed on pilot projects that examine the relationship between obesity and cardiovascular diseases, type 2 diabetes, COVID-19, cancer, or neurodegenerative diseases.  These pilot grants are intended to assist investigators new to this area of research to generate sufficient data to be competitive for extramural funding. ... FULL STORY
Tags: Research

Neuroscience Researchers Keep Momentum Going with Online Seminar Series

Posted: 5/18/2020
Mere days after the COVID-19 pandemic forced limitations on research in laboratories, a team of neuroscience-related researchers from the UK College of Medicine figured out a way to keep the important discussions going, virtually.The team’s solution: developing an online seminar series discussing a wide variety of topics in neuroscience, which is one of the six research priority areas in the UK Vice President for Research’s Research Priorities Initiative.Lance Johnson, PhD, assistant professor in the department of physiology and researcher with the UK Sanders-Brown Center on Aging, said the idea derived from an interaction with a colleague from Europe, Dr. Rik van der... FULL STORY
Tags: UK Sanders-Brown Center on Aging, Neuroscience, Research

UK Launches Clinical Trial to Evaluate Novel Treatments for COVID-19

Posted: 5/8/2020
Clinical leaders from the University of Kentucky’s Markey Cancer Center, College of Medicine and College of Pharmacy have launched a clinical trial for experimental therapies to treat patients infected with COVID-19. The trial will investigate the effectiveness of azithromycin, ivermectin and camostat mesylate—drugs that could inhibit replication of SARS-CoV-2, the virus that causes the disease. The three will be tested either as stand-alone therapies or in combination with the antimalarial drug hydroxychloroquine. The trial has a “pick-the-winner” design, which will allow UK researchers to rapidly understand what potential therapies appear to be effective, guiding... FULL STORY
Tags: Research

New $6.6 Million UK Study Could Change What We Know About Platelets

Posted: 4/30/2020
University of Kentucky College of Medicine researcher Sidney Whiteheart has been awarded a prestigious Outstanding Investigator Award from the National Heart, Blood and Lung Institute (NHBLI) for his research on how platelets function in hemostasis and during immune responses. The $6.6 million grant will fund the Molecular... FULL STORY
Tags: Biochemistry, Research

Bondada Named Fellow of the American Association for the Advancement of

Posted: 12/16/2019
Subbarao Bondada, professor of microbiology in the Department of Microbiology, Immunology and Molecular Genetics in the University of Kentucky College of Medicine and Markey Cancer Center, has been named a Fellow of the American Association for the Advancement of Science (AAAS). Election as an AAAS Fellow is an honor bestowed upon AAAS members by their peers.Bondada is being recognized for distinguished contributions to the field of immunology, particularly to studies of biology of normal and malignant B lymphocytes and antibody responses to bacterial polysaccharide antigens.This year 443 members have been awarded this honor by AAAS because of their... FULL STORY
Tags: Research, Immunology, Microbiology

College of Medicine professor appointed to Kentucky Council on

Posted: 12/3/2019
Luke H. Bradley, PhD, Chellgren Endowed Professor in the department of neuroscience, was recently selected by the Kentucky Council on Postsecondary Education as a member of its newly-established Faculty Advisory Network.Dr. Bradley will join 19 other appointed members from Kentucky colleges and universities on a diverse team dedicated to promoting student success across the state. As a team member, he will advise the group and provide insight on state-level policies and initiatives based on his perspective as an experienced faculty member of a higher education institution. Specific focuses for the network this year include closing achievement gaps, responding to business... FULL STORY
Tags: Neuroscience, Research, Biochemistry

What Drives Inflammation in Type 2 Diabetes? Not Glucose, Says New Research

Posted: 8/30/2019
To date, the underlying causes of inflammation in obesity and Type 2 diabetes mellitus (T2DM) have been poorly understood, which has hampered efforts to develop treatments to prevent complications from a disease that is the third leading cause of death in the United States.But new research at the University of Kentucky shows that changes to mitochondria — the powerhouse of cells — drive chronic inflammation from cells exposed to certain types of fats, shattering the prevailing assumption that glucose was the culprit.Chronic inflammation fuels many of the devastating complications of Type 2 diabetes, including cardiovascular, kidney, and periodontal diseases, and is thus... FULL STORY
Tags: Research, Diabetes