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$1.6 Million Grant Looks at Role of Key Protein following Traumatic Brain Injury

Posted: 6/24/2015

Linda Van Eldik, Ph.D., director of the Sanders-Brown Center on Aging at the University of Kentucky, has received a $1.6 million grant to study the role of a key protein in the cascade of events following traumatic brain injury (TBI).

The five-year grant from the National Institute of Neurological Disorders and Stroke (NINDS) explores the role of a protein called p38a in the inflammatory response process post-brain injury in a mouse model of mild TBI. The research will also determine the potential for a small molecule inhibitor of p38a activity to suppress the inflammation, and thereby prevent neuron degeneration and the resulting behavioral impairments caused by brain injury.

"In the research community, abnormal inflammation is being targeted as a potential 'bad guy' for a host of diseases, including Alzheimer’s disease and stroke and brain injury is on that list," Van Eldik said.

Increasing evidence points to chronic, long-lasting inflammatory responses in the brain after TBI as a contributor to neurological damage and cognitive deficits, she said.

"If the p38a inhibitor is proven to interfere with the process by which inflammation damages the brain after injury, we will have a foundation for future development of treatments that might stop or... FULL STORY

Tags: Research, Grants and Funding, UK Sanders-Brown Center on Aging, Alzheimer's research
 

UK Hosts 5th Annual Barnstable Brown Research Day

Posted: 6/17/2015
The University of Kentucky’s fifth annual Barnstable Brown Obesity and Diabetes Research Day was held on May 20 at the Albert B. Chandler Hospital Pavilion A. Since 2011, the event has focused on current findings in obesity and diabetes research and features presentations by nationally prominent physician-scientists as well as the work of regional... FULL STORY
Tags: Reseach, Barnstable Brown Kentucky Diabetes and Obesity Center
 

Gill Heart Institute Doctor Assesses New Cholesterol Drugs

Posted: 6/12/2015
On the brink of FDA approval is a new class of cholesterol-lowering drugs with the potential to change the landscape in the prevention of heart attack and stroke. "These new drugs are a blockbuster as far as achieving the goal of getting LDL levels down markedly," Dr. Thomas Whayne, director of the Lipid Management Clinic at the Gill Heart... FULL STORY
Tags: Reseach, Gill Heart Institute
 

UK Scientist Awarded $3 Million NIH Grant to Study Therapy for Sepsis

Posted: 3/10/2015 - Tags: Research, Saha Cardiovascular Research Center
Xiang-An Li, Ph.D., of the University of Kentucky Saha Cardiovascular Research Center and Department of Pediatrics, has been awarded a $3 million grant from the National Institutes of Health to study synthetic HDL (sHDL) as a potential therapy for sepsis. Sepsis -- also called septicemia -- is a life-threatening condition caused by an overwhelming immune response to infection. Immune chemicals released by the body into the bloodstream to fight the infection trigger widespread inflammation that can damage multiple organ systems. In the worst cases, blood pressure drops, the heart weakens and the patient spirals toward septic shock and death. Sepsis is a major... FULL STORY

Legislative Leaders Join Gov. Beshear for UK Research Bill Signing

Posted: 3/9/2015 - Tags: Research
Governor Steve Beshear, joined by legislative leaders, today signed legislation authorizing construction of a multidisciplinary research building at the University of Kentucky. House Bill 298 provides for a state-of-the-art facility which will house world-class research across health disciplines. Research will focus on the many health challenges facing the Commonwealth, particularly those which contribute to preventable diseases and deaths. “This project represents the potential to improve the lives of so many, both within Kentucky where our health outcomes are so poor, and beyond,” Gov. Beshear said. “I’m happy the General Assembly is supporting the university’s... FULL STORY

New UK Research Facility Gets Green Light From State Legislature

Posted: 3/4/2015 - Tags: Research
University of Kentucky President Eli Capilouto believes it is time "to make death a beggar in Kentucky.” It’s the idea that through world-class research across an array of disciplines, and a commitment to working as partners with communities across the state, some of the most stubborn health challenges and statistics that plague Kentucky can be successfully attacked. On Tuesday, the state General Assembly and Gov. Steve Beshear demonstrated their unwavering commitment to that vision of addressing Kentucky’s most stubborn health disparities by endorsing funding for construction of a $265 million, multidisciplinary research building at UK. The Senate voted 36-... FULL STORY

UK Libraries Workshops to Help Users Save Time, Be More Effective With

Posted: 2/11/2015 - Tags: Research
From undergraduate students to graduate students and faculty members, everyone can use some time-saving strategies for library research. A series of workshops presented by University of Kentucky Libraries will help members of the campus community save time and be more effective in their research. The series targets a number of specific topics from basic research skills to scholarly communication issues. The UK Libraries Workshops range from 30 minutes to 90 minutes each. Upcoming workshop offerings are: · "Open Up Your Published Research: Introduction to Open Access," 3 p.m. Wednesday, Feb. 11, at William T. Young Library, Room 1-57; · "What Your Students Think... FULL STORY

UK Research Building Clears First Legislative Hurdle

Posted: 2/11/2015 - Tags: Research
The House Appropriations and Revenue Committee Tuesday strongly endorsed legislation that would provide funding for a multi-disciplinary research building on the University of Kentucky campus targeted at the Commonwealth’s most pressing challenges. “Our goal is to make death a beggar in Kentucky,” said UK President Eli Capilouto, who testified before the committee Tuesday morning. The legislation now goes to the full House for consideration. Specifically, the state would fund $132.5 million of the projected $265 million research building. UK would fund the other half. The building, which would be located on South Limestone next to the bio-pharmacy building,... FULL STORY

UK Neonatologist's Study Trial Supports Alternative Therapy for Drug-

Posted: 2/2/2015 - Tags: Research, Pediatrics
In the past decade, the number of Kentucky babies starting life with a drug dependency, or neonatal abstinence syndrome (NAS), has skyrocketed from 1.3 per 1,000 births to 19 per 1,000 births. Just like adults coming off drugs, babies whose mothers used opiate drugs during pregnancy, will suffer from a number of withdrawal symptoms, including tremors and irritability. The most common form of treatment for babies suffering from withdrawal is the opiate morphine, which can hinder brain development during a critical growth period in a baby's life. The treatment period for infants requires hospitalization and can last weeks or even months, resulting in high... FULL STORY

Registration Now Available for UK Barnstable Brown Obesity & Diabetes

Posted: 2/2/2015 - Tags: Research, Barnstable Brown Obesity and Diabetes Research Day
Registration is now available for the fifth annual Barnstable Brown Obesity... FULL STORY

UK Sanders-Brown Researcher Receives NIH Grant Totaling $1.1 Million

Posted: 1/28/2015 - Tags: UK Sanders-Brown Center on Aging, Research, Grants and Funding
Dr. Gregory J. Bix of the University of Kentucky Sanders-Brown Center on Aging, has been awarded a $1.1 million grant from the National Institutes of Health to study a promising treatment for ischemic stroke. The five-year grant expands Bix's earlier research on a protein called Perlecan Domain V, which appears to foster healing after strokes caused by blood clots in the brain. "Perlecan seems to promote neurorepair in endothelial cells by blocking a receptor called A5B1 Integrin," Bix said. "In fact, genetically engineered mice that are completely deficient in the A5B1 receptor in endothelial cells show amazingly little to no injury after a stroke." "It's... FULL STORY

UK Study Finds Potential New Drug Target for Lung Cancer

Posted: 1/23/2015 - Tags: Lung Cancer, Markey Cancer Center, Research
A new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a key enzyme and its associated metabolic programming may lead to novel drug development to treat lung cancer. Cancer cells undergo metabolic alterations to meet the increased energy demands that support their excess growth and survival. The Krebs cycle in the mitochondria of cells is used to supply both energy and building materials for cell growth. Two mitochondrial enzymes – pyruvate carboxylase (PC) and glutaminase replenish carbon to the Krebs cycle.   Published in the Journal of Clinical Investigation, the study collected metabolic data directly from more than... FULL STORY

UK Study Disputes Previous Theories on Loss of Muscle Stem Cells and Aging

Posted: 1/7/2015 - Tags: Center for Muscle Biology, CCTS, Research
Professional athletes often spend hours in a gym working to build strong healthy muscles needed to keep them at the top of their game. But strong muscles help all humans maintain peak physical performance – the non-athlete, the young and the old – and can prevent frailty later in life, a condition that can exacerbate an illness and even shorten one's life. According to Charlotte Peterson, co-director of the Center for Muscle Biology at the University of Kentucky, "muscle powers health." Peterson, who is also a professor and associate dean for research in the College of Health Sciences and associate director of the UK Center for Clinical and Translation Sciences (CCTS... FULL STORY

UK Researchers Point to Impact of Combined Brain Injury and PTSD in War

Posted: 12/22/2014 - Tags: Research, Rehabilitation Medicine
The U.S. Department of Defense identifies mild traumatic brain injury, or mTBI, as one of the signature injuries impacting veterans who served in Iraq and Afghanistan. Often associated with the blast of an improvised explosive device (IED) in the field, an mTBI is commonly diagnosed in concurrence with posttraumatic stress disorder, a separate condition triggered by the traumatic event. A recent study suggests that 12 to 16 percent of all veterans involved in the Iraqi conflict have a history of mTBI and an estimated 13 to 17 percent of veterans return with a diagnosis of PTSD resulting from an injury. One-third of all veterans with a TBI also suffer from PTSD.... FULL STORY

94 Year-Old Lexington Woman Gives Back as Research Volunteer

Posted: 12/19/2014 - Tags: Research, UK Sanders-Brown Center on Aging, Clinical Trials
On Dec. 2, a very special group of people gathered to celebrate a very special gift. "Participation in clinical trials is a truly noble act, and we consider the people who volunteer for research part of our family," says Dr. Gregory Jicha, a professor at the University of Kentucky's Sanders-Brown Center on Aging. "So it's natural that we would gather at the holidays to share a little joy and thanksgiving." Every year, the Sanders-Brown Center on Aging has a party for patients who have volunteered to participate in research at the center. It's an annual highlight for patients and staff alike, who often form special bonds over the course of several years.... FULL STORY