New Clinical Trial Takes Personalized Approach for Rare Type of ALS in

Posted: 6/13/2018
ALS, or amyotrophic lateral sclerosis, is a neurodegenerative disease of some fame in the United States. Many Americans know the illness, which currently has no cure, as Lou Gehrig’s disease, after the beloved baseball player whose career and life were cut short by the condition in the 1930s and 40s. More recently, renowned physicist Stephen Hawking died of ALS. Perhaps more than anyone else, Hawking reminds us of the particular cruelty of the disease, which slowly robs a person of muscle movement while leaving their cognitive abilities intact. The average life expectancy after diagnosis is only four to five years and nearly everyone with ALS ultimately dies from the... FULL STORY
Tags: Research, ALS

Undergraduate Research Mentor Award Winners Announced

Posted: 6/13/2018
 Luke Bradley, Janice Fernheimer and Gregory Luhan received the University of Kentucky 2018 Excellent Undergraduate Research Mentor Award. This student-nominated award recognizes UK faculty members who demonstrate an outstanding commitment to mentoring undergraduate researchers, providing exceptional undergraduate research experiences, as well as supporting and promoting the undergraduate research initiatives on campus.Eighteen faculty mentors were nominated for the award by their students.Bradley is an associate professor and research mentor in the Department of Neuroscienceand the Department of Molecular and Cellular... FULL STORY
Tags: Research

Students, Postdocs and Faculty Present Latest Findings at Markey Research

Posted: 5/12/2018
The University of Kentucky Markey Cancer Center recently held its ninth annual Markey Cancer Center Research Day, highlighting the work of UK students, postdoctoral fellows and faculty from the past year.Research Day provides an opportunity for investigators to showcase their work and also view the work of their colleagues across the campus. Markey researchers are housed all across the University, spanning eight colleges and 28 departments.This year’s event featured 142 posters and oral presentations from a graduate student, postdoctoral fellow, two medical fellows, and a junior faculty member. The afternoon’s faculty oral presentations comprised six research... FULL STORY
Tags: Research, Markey Cancer Center

UK Honors the 2018-2019 University Research Professors

Posted: 5/3/2018
This week, it was my distinct pleasure to present the University Research Professorship Awards to 14 members of our faculty who have demonstrated excellence in research and creative work that addresses scientific, social, cultural, economic and health challenges in our region and around the world.At a reception hosted by President Eli Capilouto at Maxwell Place, with their families, deans, associate deans for research and nominators on hand to celebrate with them, we had the opportunity to recognize and publicize the accomplishments of these scholars.The University Research Professorships were established by the UK Board of Trustees in 1976 to recognize outstanding... FULL STORY
Tags: Research, Awards and Recognition

Head Injuries and the Path from Pilot Study to Major Grant

Posted: 4/18/2018
Traumatic brain injury (TBI) has been a hot topic of late as soldiers return from the battlefield and football players from the gridiron with debilitating injuries.To date, treatment for TBI has been limited because the underlying mechanisms that cause brain damage are still poorly understood. Recently, however, science has shown increased interest in exploring ways to prompt the brain to heal itself after injury, or perhaps even protect itself as the injury occurs.A team of researchers from the University of Kentucky Department of Molecular and Cellular Biochemistry, the Spinal Cord and Brain Injury Research Center (SCoBIRC), and the Sanders-Brown Center on Aging have... FULL STORY
Tags: Research, Grant

CCTS Conference on Opioids Draws Nearly 1,000 Participants

Posted: 4/17/2018
The 13th Annual Spring Conference of the University of Kentucky Center for Clinical and Translational Science (CCTS) was held April 13 at the Lexington Convention Center. While the CCTS supports research across the spectrum of diseases, this year’s conference focused on using translational science to address the opioid epidemic.Nearly 1,000 researchers, clinicians, students, trainees, community partners and local and national experts participated in the day-long, multidisciplinary event to share their findings and enhance collaborations. In addition to plenary presentations by nationally renowned speakers, around 300 posters were presented, along with... FULL STORY
Tags: CCTS, Research

Annual Report Spotlights UK Research Impact on Kentucky

Posted: 4/9/2018
How is research at the University of Kentucky transforming tomorrow? The UK Research 2017 Annual Report shares the economic impact of UK research, strategic plan progress, national rankings and innovative federally funded research projects in substance abuse, cancer, diabetes and obesity, cardiovascular diseases, neuroscience and aging, and energy.In 2017, UK investigators brought in $331.3 million in research awards. Of that total, $178.3 million were federal grants, including $113.9 million from the National Institutes of Health. Industry contracts to UK totaled $18.1 million. “We believe in the powerful idea that brainpower, harnessed in common cause against... FULL STORY
Tags: Research

Sanders-Brown Grant Trains New Generation of Dementia Researchers

Posted: 4/2/2018
The University of Kentucky Sanders-Brown Center on Aging has been awarded a $2 million grant by the National Institutes of Health to train the next generation of dementia researchers. The T32 training grant, “Training in Traditional Research in Alzheimer’s Disease and Related Dementias (TRIAD),” is the first Sanders-Brown Center on Aging training grant dedicated to Alzheimer’s disease and related dementias.The program provides cross-disciplinary, bench-to-bedside training for all trainees. “We have really fantastic faculty, so our trainees will be exposed to high-caliber mentorship that prepares them for a research career in an area of dire need,” said Elizabeth... FULL STORY
Tags: Research, UK Sanders-Brown Center on Aging

SCoBIRC Symposium Receives Broad Attendance

Posted: 3/19/2018
 The 24th Annual Kentucky Spinal Cord & Head Injury Research Trust Symposium, was held on Thursday, May 10, 2018, in the Lee T. Todd, Jr. Building at the University of Kentucky.Prominent researchers in the fields of spinal cord and traumatic brain injury from across the nation joined the UK Spinal Cord and Brain Injury Research Center (SCoBIRC) faculty to share information focused on two themes: long-term consequences of neurotrauma and research along the translational spectrum.Speakers examining the long-term consequences of neurotrauma included Drs. Mark Burns(Georgetown University), Warren Alilain (SCoBIRC), ... FULL STORY
Tags: scobirc, Research

New Study Shows Repurposing Leukemia Drugs May Prevent Melanoma Metastasis

Posted: 2/26/2018
Data from a new study led by University of Kentucky Markey Cancer Center researchers shows that repurposing drugs used to treat leukemia has promise for preventing melanoma metastasis.Published in Science Signaling, the study showed new evidence linking the activation of ABL kinases – cancer-promoting genes – to the secretion of pro-metastatic cathepsins in melanoma. Cathepsins are enzymes that degrade proteins and are highly expressed in cancer cells, resulting in their release into the environment between the cells. These enzymes "chew up" the fibrous matrix around tumors, which allows them to get into the blood stream and lymphatic system and spread around... FULL STORY
Tags: Pharmacology and Nutritional Sciences, Research

Are Humans 'Smeller Underachievers?' Not So Fast…

Posted: 2/26/2018
Historically speaking, smell is the Rodney Dangerfield of the human senses. A series of scientific mischaracterizations rooted in (of all things) the religious politics of 19th century France and perpetuated by scientists like Sigmund Freud led to widespread acceptance that humans were underachievers in the smelling category. But a growing number of scientists are rewriting the script, advancing the argument that smell has a powerful influence on emotions and behavior. "We all have heard the hypothetical question, 'Would you rather lose your eyesight or your sense of smell?'" said John McGann, an associate professor at Rutgers University. "Most people would rather... FULL STORY
Tags: Physiology, Research

People Behind Our Research: Sally Ellingson Uses Big Data and Machine

Posted: 2/26/2018
From childhood excellence in art and math, Sally Ellingson has built a robust career in computational drug discovery. The graduate of joint program with the University of Tennessee and Oakridge National Laboratory, Ellingson is an assistant professor of biomedical informatics in the UK College of Medicine and manages high-performance computing for the UK Markey Cancer CenterCancer Research Informatics Shared Resource Facility.A central aim of her research is to increase the accuracy of predicting whether or not a drug will bind to a protein, which is useful across the board of drug development.“With machine learning, you can add biomedical big... FULL STORY
Tags: Research