Predicting How Healthy Your Heart Will be Years Down the Road

Posted: 10/17/2017
Picture this: you're battling heart failure and meeting with your doctor to discuss treatment. Before prescribing anything, the doctor pulls up a virtual model of your heart on her computer and "treats" it with several drugs. A few moments later, she can see how your heart is doing five years down the road.Your doctor chooses the treatment with the best long-term outcome, and you live a longer and healthier life.Two University of Kentucky researchers are working to make this experience a reality for the 5.7 million adults in the U.S. with heart failure.Combining physiology and engineering, UK's Kenneth Campbell and Jonathan Wenk are developing... FULL STORY
Tags: Physiology, Research

Sanders-Brown Markesbery Symposium Focuses on Why Some People Don't

Posted: 10/13/2017
Why do some people stay intellectually sharp into their 90s, while others have memory problems?  Is there anything we can learn from their lifestyles that can help everyone age successfully?These are among topics scheduled for the University of Kentucky Sanders-Brown Center on Aging's Markesbery Symposium on Nov. 3-4.  Keynote speakers are:Dr. Claudia Kawas of the 90+ Study which explores the fastest-growing age group in the U.S.:  "The oldest old." Kawas appeared in a 2014 “60 Minutes” episode called Living to 90 and Beyond that explored the secrets to a long and happy life.Rachel Whitmer, a national expert on risk... FULL STORY
Tags: Research, UK Sanders-Brown Center on Aging

Markey's Blackburn Earns NIH New Innovator Award for Cancer Research

Posted: 10/6/2017
 University of Kentucky Markey Cancer Center Researcher Jessica Blackburn has earned a prestigious National Institutes of Health's New Innovator Award, a grant totaling $1.5 million over five years to fund pediatric cancer research.Blackburn, an assistant professor in the UK Department of Molecular and Cellular Biochemistry, runs a basic science laboratory using zebrafish as an animal model. This new award will specifically fund research to find causes of leukemia relapse in three ways:Identifying the unique genetic signature of relapse-causing cells, using single-cell sequencing technology in both zebrafish leukemia models and patient samples.Discovering... FULL STORY
Tags: Research, Biochemistry

Sanders-Brown Awarded Grant to Study Alzheimer's Prevention Drug

Posted: 10/6/2017
The National Institutes of Health has awarded a five year, $2.88 million grant to a Sanders-Brown Center on Aging researcher to study a drug's potential to prevent Alzheimer's disease.Researchers have known for decades that the hallmark plaques and tangles in the brain associated with Alzheimer's develop long before people experience memory loss. Ai-Ling Lin, an assistant professor at Sanders-Brown, hopes to demonstrate that low doses of Rapamycin, a drug commonly used as an immunosuppressant for organ transplant recipients, can restore brain function before the disease changes in the brain affect a person's memory."We know that Rapamycin signals blood vessels to... FULL STORY
Tags: Research, UK Sanders-Brown Center on Aging

KEHA Marks 40 Years of Support for UK Ovarian Cancer Research

Posted: 10/4/2017
A fundraising effort that began with an impassioned plea from one extension homemaker to her peers has positively impacted Kentucky women and the University of Kentucky for the past 40 years.The late Virginia McCandless, a Barren County extension homemaker, and Dr. John van Nagell with the UK Markey Cancer Center started the ovarian cancer research fundraising effort in 1977. At the time, McCandless was state health chair for the Kentucky Extension Homemaker’s Association and diagnosed with ovarian cancer. She approached van Nagell, her gynecologic oncologist, about ways to raise awareness about the cancer — often known as the “silent killer... FULL STORY
Tags: Research, community health and involvement, obstetrics

UK Researchers Seek to Identify Ways to Relieve Post-Chemotherapy

Posted: 9/29/2017
Of the 14 million cancer survivors in the United States, a significant number experience a serious side effect called chemotherapy-induced cognitive impairment (CICI). While easily recognized, little is known about the etiology of this condition, also known informally as “chemo brain.” CICI can significantly reduce patients’ quality of life with serious, even devastating, symptoms such as memory lapses, difficulty concentrating, negative impacts on multitasking, confusion and fatigue.Three University of Kentucky Markey Cancer Center researchers are tackling this problem head-on, serving as principal investigators on a new $2.3 million grant awarded by the National... FULL STORY
Tags: Research, Markey Cancer Center

Achieving Health Equity: Tools for a National Campaign Against Racism is

Posted: 9/12/2017
Epidemiologist Dr. Camara Phyllis Jones will present the next installment of the University of Kentucky College of Medicine Dean's Distinguished Lecture Series, "Achieving Health Equity: Tools for a National Campaign Against Racism."Jones is research director on social determinants of health and equity for the U.S. Centers for Disease Control and Prevention.  She is a family physician and epidemiologist whose work focuses on the impact of racism on the health and well-being of the nation.She seeks to broaden the national health debate to include not only universal access to high-quality health care but also attention to the social determinants of... FULL STORY
Tags: DDLS, Research

UK Partners with Community to Answer Environmental Health Questions

Posted: 8/7/2017
The University of Kentucky was awarded a five-year, $7.4 million National Institute of Environmental Health Sciences (NIEHS) grant to establish the UK Center for Appalachian Research in Environmental Sciences (UK-CARES). This center will foster research across all spectrums — basic, clinical, epidemiological and translational—to identify environmental factors and underlying mechanisms responsible for the disproportionately high incidence of chronic diseases, such as colorectal cancer, lung cancer, cardiovascular disease, obesity and diabetes, in Appalachian Kentucky. “This grant represents that type of leading-edge research and creative scholarship that... FULL STORY
Tags: Research, Rural Health

New Study Discovers "Killer Peptide" That Helps Eliminate

Posted: 8/4/2017
A new study by University of Kentucky Markey Cancer Center researchers shows that when therapy-sensitive cancer cells die, they release a "killer peptide" that can eliminate therapy-resistant cells.Tumor relapse is a common problem following cancer treatment, because primary tumor cells often contain therapy-resistance cancer cells that continue to proliferate after the therapy-sensitive cells have been eliminated.In the new study, published in Cancer Research, Markey scientists identified a Par-4 amino-terminal fragment (PAF) that is released by diverse therapy-sensitive cancer cells following therapy-induced cleavage of the tumor suppressor Par-4... FULL STORY
Tags: Research, Cancer

Matthew Gentry: Biofuels, Epilepsy and Science Advocacy

Posted: 7/26/2017
By Vice President for Research Lisa Cassis ThursdayIn May, it was my distinct pleasure to present Matthew Gentry with a University Research Professorship award. He was one of 16 faculty, selected by their own colleges, who have demonstrated excellence in scholarship and creative work that addresses scientific, social, cultural and economic challenges in our region and around the world.Gentry, a professor of molecular and cellular biochemistry in the College of Medicine, has received an NSF Faculty Career Development Award, NIH Pathway to Independence Award, three U.S. patents, and a five-year, $8.5 million NIH grant to pursue a cure for Lafora disease, a deadly... FULL STORY
Tags: Research

Physician-Pharmacist Teams Benefit Brain Health in Older Patients

Posted: 7/19/2017
New findings from University of Kentucky faculty published in Alzheimer’s Research and Therapy demonstrate the value of physician-pharmacist teams in providing elderly care.As people age, the number of prescribed medications tends to increase, raising the level of complexity for both patient care and medication therapy. In the United States, patients over 60 take an average of five different medications, many of which are prescribed by different physicians. This complexity often results in a higher probability of inappropriate drug prescriptions and side effects, including cognitive impairment.This is especially relevant for patients living with Alzheimer’s... FULL STORY
Tags: Research

The People Behind Our Research: "You Have to Follow the Science Where

Posted: 7/17/2017
A peek at Matthew Gentry's professional profile reveals a long list of honors and awards.A National Science Foundation Faculty Career Development Award.A National Institutes of Health Pathway to Independence Award.A University of Kentucky Research Professorship Award.Three U.S. Patents.A five-year, $8.5 million National Institutes of Health grant to pursue a cure for Lafora disease.Wait. Lafora disease? From a lab that also studies biofuels?"I began my career studying plant proteins and am now working on human diseases," Gentry says. "You have to be willing to go where the science takes you."In Gentry's case, the journey began when he found that a certain plant protein... FULL STORY
Tags: Research