New Study Shows Promise for Repurposing Anti-Malarial Drug for Cancer

Posted: 1/10/2017 - Tags: Markey Cancer Center, Research
A new study by University of Kentucky Markey Cancer Center researchers shows that chloroquine – a drug currently used to treat malaria – may be useful in treating patients with metastatic cancers. Published in Cell Reports, the study showed that chloroquine induced the secretion of the tumor suppressor protein Par-4 in both mouse models and in cancer patients in a clinical trial. Secreted Par-4 is essential for tumor cell death and the inhibition of tumor metastasis. Chloroquine induces Par-4 secretion via the classical secretory pathway that requires activation of p53 (a mutation of the p53 protein, or disturbances in the pathways that signal to p53, is common in... FULL STORY

Tindall-Staton Finds Passion in Research Close to Her Heart

Posted: 1/9/2017 - Tags: Research, Behavioral Science, Faculty
Michele Staton-Tindall grew up in rural Appalachia during a time when people felt so safe they didn’t even lock their doors at night. The ensuing drug epidemic that now ravages her former home has dramatically impacted the lives of the Appalachian people and broken that sense of security.Staton-Tindall, an associate professor in the  Department of Behavioral Science at the University of Kentucky's College of Medicine, and a faculty associate at the Center on Drug and Alcohol Research, has made it her mission to make a positive difference in the Appalachian area, particularly for women in the criminal justice population who have fallen prey to... FULL STORY

Daugherty is Editor-in-Chief of American Heart Association Journal for

Posted: 1/4/2017 - Tags: Faculty, Research, Cardiovascular, Publications
Alan Daugherty, senior associate dean for research at the University of Kentucky College of Medicine, was recently approved to renew his contract as editor-in-chief of Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association (ATVB) for a second five-year term. ATVB is one of the five core journals of the American Heart Association. As editor of ATVB, Daugherty’s primary focus is on publishing the most important new research studies related to a spectrum of vascular diseases. “We’re also committed to presenting fair and balanced reviews of critical issues in the subject areas we cover,” he said. Daugherty also serves as director... FULL STORY

Alzheimer's Association Awards $1 Million Grant to UK Sanders-Brown

Posted: 12/9/2016 - Tags: Alzheimer's research, Research
Linda Van Eldik, director of the University of Kentucky Sanders-Brown Center on Aging, was awarded a "Part the Cloud" translational research grant from the Alzheimer's Association. This two-year, $997,738 grant will fund early clinical trials for a promising new treatment for Alzheimer's disease. Currently, Van Eldik’s team is exploring brain inflammation's role in nerve cell damage as a first step in identifying opportunities to suppress detrimental inflammatory molecules. "Brain inflammation is now recognized as an important driver of neurodegenerative disease progression and we desperately need new selective anti-inflammatory drugs to be tested in humans," said... FULL STORY

Sanders-Brown Named Site for Landmark NIH Grant

Posted: 12/6/2016 - Tags: UK Sanders-Brown Center on Aging, Research, Aging
The University of Kentucky Sanders-Brown Center on Aging (SBCoA) has been selected to participate in a multicenter, landmark $3.6 million grant from the National Institutes of Health to identify biomarkers for vascular cognitive impairment and dementia (VCID). UK was one of just seven sites selected for the five-year NIH's National Institute of Neurological Disorders and Stroke (NINDS) grant. The other sites are Boston University, Rush University, Johns Hopkins, University of Southern California, UCSF/UC-Davis and the University of New Mexico. The awards establish the new national Small Vessel VCID Biomarkers Consortium. "We're thrilled to be collaborating with... FULL STORY

UK Faculty Receive Funding to Develop Responses to Opioid Injection

Posted: 12/1/2016 - Tags: Research, Behavioral Science, Appalachian Kentucky
Two faculty members from the University of Kentucky have received three of four funded awards from the National Institutes of Health (NIH) to develop responses to the opioid injection epidemic that can be implemented by public health systems in rural communities. Carrie Oser, an associate professor of sociology in the UK College of Arts... FULL STORY

Markesbery Symposium Focuses on Healthy Brain Aging, Care for Caregivers

Posted: 11/9/2016 - Tags: Research, Aging
University of Kentucky Sanders-Brown Center on Aging (SBCoA) hosted its sixth annual Markesbery Symposium on Aging and Dementia last week with speakers focused on brain health and self-care for caregivers. The two-day program offered sessions for both scientific and community audiences. On Friday, Nov. 4, the scientific session in the UK Chandler Hospital Pavilion A auditorium featured speakers Dr. Gary Small of UCLA and Dr. Julie Schneider of Rush University, who presented their latest findings and answered questions from the audience. Schneider provided an overview of her observations that, there are brain changes in addition to the well-characterized... FULL STORY

Gill Heart Institute Cardiovascular Research Day Presents Scientific

Posted: 11/7/2016 - Tags: Gill Heart Institute, Research
Clinicians and basic scientists convened to discuss challenges, triumphs and future directions in cardiovascular disease research during the 19th Annual Gill Heart Institute Cardiovascular Research Day on Nov. 4. Hosted by the UK Gill Heart Institute, the annual research day showcased scientific advancement in understanding and treating the various diseases of the blood vessels and heart. Topics presented at the conference ranged from identifying genomic markers correlated with heart disease to urging members of the public to put CPR training to action during an emergency. Burgeoning scientists and trainees throughout the region were provided the opportunity to... FULL STORY

Proposed Clinical Trial Could Change the Game for Deadly Type of Breast

Posted: 11/3/2016 - Tags: Research, Markey Cancer Center, Clinical Trials
University of Kentucky Markey Cancer Center Oncologist Dr. Edward Romond spent his career at UK treating and studying breast cancer, even leading major Phase 3 clinical trials on the breast cancer drug trastuzumab in the early 2000s. Commonly known as Herceptin, this drug became a standard of care for patients with HER2-positive breast cancer.Though he retired from practice last year, Romond continues to work part-time with the research team at Markey, this time pushing toward a cure for a different, more deadly, type of breast cancer. "Breast cancer, we now recognize, is at least five different disease that are completely different from each other," Romond said. "... FULL STORY

Getchell Memorial Award Honors Graduate Scientist's Persistence in

Posted: 11/3/2016 - Tags: Awards and Recognition, Research
The second annual Thomas V. Getchell, Ph.D., Memorial Award for excellence in grant writing was presented to Jenna Gollihue, a graduate student in the University of Kentucky Spinal Cord and Brain Injury Research Center, on Nov. 2. The award honors the memory of Getchell, a former professor of physiology in the UK Department of Physiology who encouraged researchers to improve grant writing skills to acquire research funding. The award supports a travel stipend for a student participating in the annual Grant Writing Workshop. Getchell founded the Grant Writing Workshop in 2005 with a vision to provide proactive, individualized mentoring to medical, doctoral and post... FULL STORY

UK Receives $19.8 Million Clinical and Translational Science Award

Posted: 10/26/2016 - Tags: Research, NIH Award
The University of Kentucky Center for Clinical and Translational Science (CCTS) announced today that it received a four-year, $19.8 million Clinical and Translational Science Award (CTSA) from the National Center for Advancing Clinical and Translational Sciences at the National Institutes of Health. CTSA grants support innovative solutions to improve the efficiency, quality, and impact of translating scientific discoveries into interventions or applications that improve the health of individuals and communities.UK officials were joined by U.S. Senate Majority Leader Mitch McConnell and Congressman Andy Barr for the announcement.This is the... FULL STORY

Nika Larian Maps Interactions between Nutrients, Exposures & Diabetes

Posted: 10/20/2016 - Tags: Research
Nika Larian, a PhD student in Lisa Cassis's lab at the UK Superfund Research Center, is studying the aryl hydrocarbon receptor, or AHR, a transcription factor with roles in drug metabolism and detoxification. She explains that if you knock out AHR in the fat tissue of mice, you can prevent the development of polychlorinated biphenyl (PCB)-induced diabetes. PCBs are toxins that are present in the environment and have been linked to type 2 diabetes."I'm investigating natural components of the microbiome that are influenced by a high-fat diet, and may also be altered by exposure to PCBs. The microbiome is influenced by what we eat, including the consumption of a high-fat... FULL STORY