Publications

**2014**
Bisphenol A Increases Atherosclerosis in Pregnane X Receptor-Humanized ApoE Deficient Mice.
Sui Y, Park SH, Helsley RN, Sunkara M, Gonzalez FJ, Morris AJ, Zhou C.
J Am Heart Assoc. 2014 Apr 22;3(2):e000492. doi: 10.1161/JAHA.113.000492.
PMID: 24755147
http://www.ncbi.nlm.nih.gov/pubmed/24755147

Arguing the Case for the Autotaxin-Lysophosphatidic Acid-Lipid Phosphate Phosphatase 3-Signaling Nexus in the Development and Complications of Atherosclerosis. Smyth SS, Mueller P, Yang F, Brandon JA, Morris AJ. Arterioscler Thromb Vasc Biol. 2014 Jan 30. [Epub] PMID: 24482375
http://www.ncbi.nlm.nih.gov/pubmed/24482375

**2013**

Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. Karapetyan AV, Klyachkin YM, Selim S, Sunkara M, Ziada KM, Cohen DA, Zuba-Surma EK, Ratajczak J, Smyth SS, Ratajczak MZ, Morris AJ, Abdel-Latif A. Stem Cells Dev. 2013 Jun 1;22(11):1645-56. doi: 10.1089/scd.2012.0488. Epub 2013 Feb 19. PubMed PMID: 23282236; PubMed Central PMCID: PMC3657281
http://www.ncbi.nlm.nih.gov/pubmed/23282236

Green tea diet decreases PCB 126-induced oxidative stress in mice by up-regulating antioxidant enzymes. Newsome BJ, Petriello MC, Han SG, Murphy MO, Eske KE, Sunkara M, Morris AJ, Hennig B. J Nutr Biochem. 2013 Nov 6. pii: S0955-2863(13)00221-0. doi: 10.1016/j.jnutbio.2013.10.003. [Epub] PMID: 24378064
http://www.ncbi.nlm.nih.gov/pubmed/24378064

The native production of the sesquiterpene isopterocarpolone by Streptomyces sp. RM-14-6.
Shaaban KA, Singh S, Elshahawi SI, Wang X, Ponomareva LV, Sunkara M, Copley
GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. Nat Prod Res. 2013
Nov 18. [Epub ahead of print] PubMed PMID: 24237421.
http://www.ncbi.nlm.nih.gov/pubmed/24237421

A Diastereoselective Oxa-Pictet-Spengler-Based Strategy for (+)-Frenolicin B
and epi-(+)-Frenolicin B Synthesis.
Zhang Y, Wang X, Sunkara M, Ye Q, Ponomereva LV, She QB, Morris AJ, Thorson
JS. Org Lett. 2013 Nov 1;15(21):5566-9. doi:
10.1021/ol4027649. Epub 2013 Oct 23. PubMed PMID: 24151973.
http://www.ncbi.nlm.nih.gov/pubmed/24151973

Syntheses of deuterium labeled prenyldiphosphate and prenylcysteine analogues for
in vivo mass spectrometric quantification. Subramanian T, Subramanian KL, Sunkara M, Onono FO, Morris AJ, Spielmann HP.
J Labelled Comp Radiopharm. 2013 Jun
30;56(8):370-5. doi: 10.1002/jlcr.3049. Epub 2013 May 9. PubMed PMID: 24285475.
http://www.ncbi.nlm.nih.gov/pubmed/24285475

Integrin-mediated cell surface recruitment of autotaxin promotes persistent
directional cell migration.
Wu T, Vander Kooi C, Shah P, Charnigo R, Huang C, Smyth SS, Morris AJ.
FASEB J. 2013 Nov 25. [Epub ahead of print] PubMed
PMID: 24277575.
http://www.ncbi.nlm.nih.gov/pubmed/24277575

Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2.
Shaaban KA, Singh S, Elshahawi SI, Wang X, Ponomareva LV, Sunkara M, Copley
GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. J Antibiot (Tokyo). 2013 Nov 20.
doi: 10.1038/ja.2013.113. [Epub ahead of print] PubMed PMID: 24252813.
http://www.ncbi.nlm.nih.gov/pubmed/24252813

Amlodipine Reduces AngII-Induced Aortic
Aneurysms and Atherosclerosis in Hypercholesterolemic Mice.
Chen X, Rateri DL, Howatt DA, Balakrishnan A, Moorleghen JJ, Morris AJ,
Charnigo R, Cassis LA, Daugherty A. PLoS One. 2013 Nov
14;8(11):e81743. doi: 10.1371/journal.pone.0081743. PubMed PMID: 24244746; PubMed
Central PMCID: PMC3828247
http://www.ncbi.nlm.nih.gov/pubmed/24244746

Autophagy and oxidative stress in gliomas with IDH1 mutations.
Acta Neuropathol. Gilbert MR, Liu Y, Neltner J, Pu H, Morris A, Sunkara M, Pittman T, Kyprianou
N, Horbinski C. ePub 2013 Oct 23. PMID: 24150401.
http://www.ncbi.nlm.nih.gov/pubmed/24150401

Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes.
Baker NA, English V, Sunkara M, Morris AJ, Pearson KJ, Cassis LA.
J Nutr Biochem. 2013 Dec;24(12):2168-74. doi: 10.1016/j.jnutbio.2013.08.009.
PMID: 24231106
http://www.ncbi.nlm.nih.gov/pubmed/24231106

Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. Xiang B, Zhang G, Guo L, Li XA, Morris AJ, Daugherty A, Whiteheart SW, Smyth SS, Li Z. Nat Commun. 2013 Oct 23;4:2657. doi: 10.1038/ncomms3657. PMID: 24150174
http://www.ncbi.nlm.nih.gov/pubmed/24150174

A Diastereoselective Oxa-Pictet-Spengler-Based Strategy for (+)-Frenolicin B
and epi-(+)-Frenolicin B Synthesis. Zhang Y, Wang X, Sunkara M, Ye Q, Ponomereva LV, She QB, Morris AJ, Thorson JS. Org Lett. 2013 Oct 23. [Epub]
PubMed PMID: 24151973.
http://www.ncbi.nlm.nih.gov/pubmed/24151973

Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation.
Park GY, Lee YG, Berdyshev E, Nyenhuis S, Du J, Fu P, Gorshkova IA, Li Y,
Chung S, Karpurapu M, Deng J, Ranjan R, Xiao L, Jaffe HA, Corbridge SJ, Kelly EA,
Jarjour NN, Chun J, Prestwich GD, Kaffe E, Ninou I, Aidinis V, Morris AJ, Smyth
SS, Ackerman SJ, Natarajan V, Christman JW. Autotaxinproduction of
Am J Respir Crit
Care Med. 2013 Sep 19. PubMed PMID: 24050723.
http://www.ncbi.nlm.nih.gov/pubmed/24050723

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.
Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago
T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR,
McEver RP, Chen H, Kahn ML, Xia L. Nature. 2013 Sep 1. doi:
10.1038/nature12501. PubMed PMID: 23995678.
http://www.ncbi.nlm.nih.gov/pubmed/23995678

Herbimycins D-F, Ansamycin Analogues from Streptomyces sp. RM-7-15.
Shaaban KA, Wang X, Elshahawi SI, Ponomareva LV, Sunkara M, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS.
J Nat Prod. 2013 Aug 15.
PMID: 23947794. http://www.ncbi.nlm.nih.gov/pubmed/23947794

Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice.
Salous AK, Panchatcharam M, Sunkara M, Mueller P, Dong A, Wang Y, Graf GA, Smyth SS, Morris AJ.
J Lipid Res. 2013 Aug 15.
PMID:23948545. http://www.ncbi.nlm.nih.gov/pubmed/23948545

Frenolicins C-G, Pyranonaphthoquinones from Streptomyces sp. RM-4-15. Wang X, Shaaban KA, Elshahawi SI, Ponomareva LV, Sunkara M, Zhang Y, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS.
J Nat Prod. 2013 Aug 14.
PMID: 23944931. http://www.ncbi.nlm.nih.gov/pubmed/23944931

Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. Onono F, Subramanian T, Sunkara M, Subramanian L, Spielmann HP, Morris AJ.
Biol Chem. 2013 Aug 1.
PMID: 23908355. http://www.ncbi.nlm.nih.gov/pubmed/23908355

Structural and Functional Characterization of CalS11, a TDP-Rhamnose 3'-O-Methyltransferase Involved in Calicheamicin Biosynthesis. Singh S, Chang A, Helmich KE, Bingman CA, Wrobel RL, Beebe ET, Makino SI, Aceti DJ, Dyer K, Hura GL, Sunkara M, Morris AJ, Phillips GN Jr, Thorson JS.
ACS Chem Biol. 2013 May 23.
PMID: 23662776. http://www.ncbi.nlm.nih.gov/pubmed/23662776

Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy. Schneider G, Bryndza E, Abdel-Latif A, Ratajczak J, Maj M, Tarnowski M, Klyachkin YM, Houghton P, Morris AJ, Vater A, Klussmann S, Kucia M, Ratajczak MZ.
Mol Cancer Res. 2013 Jul;11(7):793-807. doi: 10.1158/1541-7786.MCR-12-0600. Epub 2013 Apr 24.
PMID: 23615526. http://www.ncbi.nlm.nih.gov/pubmed/23615526

Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration. Li X, Zhou Q, Sunkara M, Kutys ML, Wu Z, Rychahou P, Morris AJ, Zhu H, Evers BM, Huang C.
J Cell Sci. 2013 Jun 15;126(Pt 12):2617-28. doi: 10.1242/jcs.117044. Epub 2013 Apr 9.
PMID: 23572508. http://www.ncbi.nlm.nih.gov/pubmed/23572508

Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance. Spencer M, Finlin BS, Unal R, Zhu B, Morris AJ, Shipp LR, Lee J, Walton RG, Adu A, Erfani R, Campbell M, McGehee RE Jr, Peterson CA, Kern PA.
Diabetes. 2013 May;62(5):1709-17. doi: 10.2337/db12-1042. Epub 2013 Jan 17.
PMID: 23328126. http://www.ncbi.nlm.nih.gov/pubmed/23328126

Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. Karapetyan AV, Klyachkin YM, Selim S, Sunkara M, Ziada KM, Cohen DA, Zuba-Surma EK, Ratajczak J, Smyth SS, Ratajczak MZ, Morris AJ, Abdel-Latif A.
Stem Cells Dev. 2013 Jun 1;22(11):1645-56. doi: 10.1089/scd.2012.0488. Epub 2013 Feb 19.
PMID: 23282236. http://www.ncbi.nlm.nih.gov/pubmed/23282236

Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells--implications for tissue regeneration. Kim C, Schneider G, Abdel-Latif A, Mierzejewska K, Sunkara M, Borkowska S, Ratajczak J, Morris AJ, Kucia M, Ratajczak MZ.
Stem Cells. 2013 Mar;31(3):500-10. doi: 10.1002/stem.1291.
PMID: 23193025. http://www.ncbi.nlm.nih.gov/pubmed/23193025

**2012**

Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation. Mitra MS, Chen Z, Ren H, Harris TE, Chambers KT, Hall AM, Nadra K, Klein S, Chrast R, Su X, Morris AJ, Finck BN.
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):642-7. doi: 10.1073/pnas.1213493110. Epub 2012 Dec 24.
PMID: 23267081. http://www.ncbi.nlm.nih.gov/pubmed/23267081

The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism. Xiang B, Zhang G, Ren H, Sunkara M, Morris AJ, Gartner TK, Smyth SS, Li Z.
PLoS One. 2012;7(12):e51037. doi: 10.1371/journal.pone.0051037. Epub 2012 Dec 6.
PMID: 23236426. http://www.ncbi.nlm.nih.gov/pubmed/23236426

Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia. Panchatcharam M, Miriyala S, Salous A, Wheeler J, Dong A, Mueller P, Sunkara M, Escalante-Alcalde D, Morris AJ, Smyth SS.
Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):52-9. doi: 10.1161/ATVBAHA.112.300527. Epub 2012 Oct 25.
PMID: 23104851. http://www.ncbi.nlm.nih.gov/pubmed/23104851

The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate. Mendoza A, Bréart B, Ramos-Perez WD, Pitt LA, Gobert M, Sunkara M, Lafaille JJ, Morris AJ, Schwab SR.
Cell Rep. 2012 Nov 29;2(5):1104-10. doi: 10.1016/j.celrep.2012.09.021. Epub 2012 Oct 25.
PMID: 23103166. http://www.ncbi.nlm.nih.gov/pubmed/23103166

Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice. Baker NA, Karounos M, English V, Fang J, Wei Y, Stromberg A, Sunkara M, Morris AJ, Swanson HI, Cassis LA.
Environ Health Perspect. 2013 Jan;121(1):105-10. doi: 10.1289/ehp.1205421. Epub 2012 Oct 24.
PMID: 23099484. http://www.ncbi.nlm.nih.gov/pubmed/23099484

Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury. Dong A, Sunkara M, Panchatcharam M, Salous A, Selim S, Morris AJ, Smyth SS.
Adv Hematol. 2012;2012:924042. doi: 10.1155/2012/924042. Epub 2012 Aug 7.
PMID: 22919395. http://www.ncbi.nlm.nih.gov/pubmed/22919395

Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/- mice fed on a high-fat diet. Deevska GM, Sunkara M, Morris AJ, Nikolova-Karakashian MN.
Biosci Rep. 2012 Oct;32(5):479-90. doi: 10.1042/BSR20120036.
PMID: 22712892. http://www.ncbi.nlm.nih.gov/pubmed/22712892

Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.
Gellett AM, Kharel Y, Sunkara M, Morris AJ, Lynch KR.
Biochem Biophys Res Commun. 2012 Jun 15;422(4):758-63. doi: 10.1016/j.bbrc.2012.05.077. Epub 2012 May 22.
PMID: 22627129. http://www.ncbi.nlm.nih.gov/pubmed/22627129

The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid. Liu J, Liang S, Liu X, Brown JA, Newman KE, Sunkara M, Morris AJ, Bhatnagar S, Li X, Pujol A, Graf GA.
J Lipid Res. 2012 Jun;53(6):1071-9. doi: 10.1194/jlr.M022160. Epub 2012 Apr 6.
PMID: 22493092. http://www.ncbi.nlm.nih.gov/pubmed/22493092

Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice.
Federico L, Ren H, Mueller PA, Wu T, Liu S, Popovic J, Blalock EM, Sunkara M, Ovaa H, Albers HM, Mills GB, Morris AJ, Smyth SS.
Mol Endocrinol. 2012 May;26(5):786-97. doi: 10.1210/me.2011-1229. Epub 2012 Apr 3.
PMID: 22474126. http://www.ncbi.nlm.nih.gov/pubmed/22474126

Lack of lipid phosphate phosphatase-3 in embryonic stem cells compromises neuronal differentiation and neurite outgrowth. Sánchez-Sánchez R, Morales-Lázaro SL, Baizabal JM, Sunkara M, Morris AJ, Escalante-Alcalde D.
Dev Dyn. 2012 May;241(5):953-64. doi: 10.1002/dvdy.23779.
PMID: 22434721. http://www.ncbi.nlm.nih.gov/pubmed/22434721

Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells. Cantrell Stanford J, Morris AJ, Sunkara M, Popa GJ, Larson KL, Özcan S.
J Biol Chem. 2012 Apr 13;287(16):13457-64. doi: 10.1074/jbc.M111.268185. Epub 2012 Mar 2.
PMID: 22389505. http://www.ncbi.nlm.nih.gov/pubmed/22389505

S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Golan K, Vagima Y, Ludin A, Itkin T, Cohen-Gur S, Kalinkovich A, Kollet O, Kim C, Schajnovitz A, Ovadya Y, Lapid K, Shivtiel S, Morris AJ, Ratajczak MZ, Lapidot T.
Blood. 2012 Mar 15;119(11):2478-88. doi: 10.1182/blood-2011-06-358614. Epub 2012 Jan 25.
PMID: 22279055. http://www.ncbi.nlm.nih.gov/pubmed/22279055

Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor K, Morris AJ, Sunkara M, Weiss HL, Lee EY, Evers BM.
Cancer Res. 2012 Mar 15;72(6):1504-17. doi: 10.1158/0008-5472.CAN-11-4057. Epub 2012 Jan 19.
PMID: 22266115. http://www.ncbi.nlm.nih.gov/pubmed/22266115

**2011**

Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS.
Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):24-32. doi: 10.1161/ATVBAHA.111.234708. Epub 2011 Oct 20.
PMID: 22015657. http://www.ncbi.nlm.nih.gov/pubmed/22015657

Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL.
Int J Toxicol. 2011 Dec;30(6):619-38. doi: 10.1177/1091581811422413. Epub 2011 Oct 12.
PMID: 21994240. http://www.ncbi.nlm.nih.gov/pubmed/21994240

Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. Zhang G, Xiang B, Ye S, Chrzanowska-Wodnicka M, Morris AJ, Gartner TK, Whiteheart SW, White GC 2nd, Smyth SS, Li Z.
J Biol Chem. 2011 Nov 11;286(45):39466-77. doi: 10.1074/jbc.M111.239608. Epub 2011 Sep 22.
PMID: 21940635. http://www.ncbi.nlm.nih.gov/pubmed/21940635

PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. Wu Z, Li X, Sunkara M, Spearman H, Morris AJ, Huang C.
PLoS One. 2011;6(9):e24775. doi: 10.1371/journal.pone.0024775. Epub 2011 Sep 12.
PMID: 21931851. http://www.ncbi.nlm.nih.gov/pubmed/21931851

A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients. Ratajczak MZ, Kim CH, Abdel-Latif A, Schneider G, Kucia M, Morris AJ, Laughlin MJ, Ratajczak J.
Leukemia. 2012 Jan;26(1):63-72. doi: 10.1038/leu.2011.242. Epub 2011 Sep 2. Review.
PMID: 21886175. http://www.ncbi.nlm.nih.gov/pubmed/21886175

Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. Fulkerson Z, Wu T, Sunkara M, Kooi CV, Morris AJ, Smyth SS.
J Biol Chem. 2011 Oct 7;286(40):34654-63. doi: 10.1074/jbc.M111.276725. Epub 2011 Aug 10.
PMID: 21832043. http://www.ncbi.nlm.nih.gov/pubmed/21832043

Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME.
Cell Metab. 2011 Aug 3;14(2):208-18. doi: 10.1016/j.cmet.2011.06.007.
PMID: 21803291. http://www.ncbi.nlm.nih.gov/pubmed/21803291

Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. Selim S, Sunkara M, Salous AK, Leung SW, Berdyshev EV, Bailey A, Campbell CL, Charnigo R, Morris AJ, Smyth SS.
Clin Sci (Lond). 2011 Dec;121(12):565-72. doi: 10.1042/CS20110236.
PMID: 21749329. http://www.ncbi.nlm.nih.gov/pubmed/21749329

Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways. Zhao J, He D, Berdyshev E, Zhong M, Salgia R, Morris AJ, Smyth SS, Natarajan V, Zhao Y.
Biochem J. 2011 Oct 1;439(1):45-55. doi: 10.1042/BJ20110274.
PMID: 21696367. http://www.ncbi.nlm.nih.gov/pubmed/21696367

Lipid phosphate phosphatase 3 enables efficient thymic egress. Bréart B, Ramos-Perez WD, Mendoza A, Salous AK, Gobert M, Huang Y, Adams RH, Lafaille JJ, Escalante-Alcalde D, Morris AJ, Schwab SR.
J Exp Med. 2011 Jun 6;208(6):1267-78. doi: 10.1084/jem.20102551. Epub 2011 May 16.
PMID: 21576386. http://www.ncbi.nlm.nih.gov/pubmed/21576386

piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. Huang H, Gao Q, Peng X, Choi SY, Sarma K, Ren H, Morris AJ, Frohman MA.
Dev Cell. 2011 Mar 15;20(3):376-87. doi: 10.1016/j.devcel.2011.01.004.
PMID: 21397848. http://www.ncbi.nlm.nih.gov/pubmed/21397848

Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. López-Juárez A, Morales-Lázaro S, Sánchez-Sánchez R, Sunkara M, Lomelí H, Velasco I, Morris AJ, Escalante-Alcalde D.
Glia. 2011 Apr;59(4):577-89. doi: 10.1002/glia.21126. Epub 2011 Jan 6.
PMID: 21319224. http://www.ncbi.nlm.nih.gov/pubmed/21319224

Structural basis of substrate discrimination and integrin binding by autotaxin. Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A.
Nat Struct Mol Biol. 2011 Feb;18(2):198-204. doi: 10.1038/nsmb.1980. Epub 2011 Jan 16.
PMID: 21240271. http://www.ncbi.nlm.nih.gov/pubmed/21240271

Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells. Patel RB, Kotha SR, Sherwani SI, Sliman SM, Gurney TO, Loar B, Butler SO, Morris AJ, Marsh CB, Parinandi NL.
Int J Toxicol. 2011 Feb;30(1):69-90. doi: 10.1177/1091581810388850. Epub 2010 Dec 3.
PMID: 21131602. http://www.ncbi.nlm.nih.gov/pubmed/21131602

Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. Majkova Z, Layne J, Sunkara M, Morris AJ, Toborek M, Hennig B.
Toxicol Appl Pharmacol. 2011 Feb 15;251(1):41-9. doi: 10.1016/j.taap.2010.11.013. Epub 2010 Dec 1.
PMID: 21130106. http://www.ncbi.nlm.nih.gov/pubmed/21130106

**2010**

Lipin proteins form homo- and hetero-oligomers. Liu GH, Qu J, Carmack AE, Kim HB, Chen C, Ren H, Morris AJ, Finck BN, Harris TE.
Biochem J. 2010 Nov 15;432(1):65-76. doi: 10.1042/BJ20100584.
PMID: 20735359. http://www.ncbi.nlm.nih.gov/pubmed/20735359

A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis. Ren H, Federico L, Huang H, Sunkara M, Drennan T, Frohman MA, Smyth SS, Morris AJ.
Mol Biol Cell. 2010 Sep 15;21(18):3171-81. doi: 10.1091/mbc.E10-01-0073. Epub 2010 Jul 21.
PMID: 20660155. http://www.ncbi.nlm.nih.gov/pubmed/20660155

A G(i) -independent mechanism mediating Akt phosphorylation in platelets. Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, Li Z.
J Thromb Haemost. 2010 Sep;8(9):2032-41. doi: 10.1111/j.1538-7836.2010.03969.x.
PMID: 20586915. http://www.ncbi.nlm.nih.gov/pubmed/20586915

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, Schuurman K, van Tellingen O, Morris AJ, Smyth SS, Moolenaar WH, Ovaa H.
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7257-62. doi: 10.1073/pnas.1001529107. Epub 2010 Apr 1.
PMID: 20360563. http://www.ncbi.nlm.nih.gov/pubmed/20360563

Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. Mathews TP, Kennedy AJ, Kharel Y, Kennedy PC, Nicoara O, Sunkara M, Morris AJ, Wamhoff BR, Lynch KR, Macdonald TL.
J Med Chem. 2010 Apr 8;53(7):2766-78. doi: 10.1021/jm901860h.
PMID: 20205392. http://www.ncbi.nlm.nih.gov/pubmed/20205392

Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. Panchatcharam M, Miriyala S, Yang F, Leitges M, Chrzanowska-Wodnicka M, Quilliam LA, Anaya P, Morris AJ, Smyth SS.
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